ID   CN-Mel
AC   CVCL_7037
SY   CNMel
DR   cancercelllines; CVCL_7037
DR   Cosmic; 1109804
DR   Cosmic; 1295332
DR   GEO; GSM276749
DR   Wikidata; Q54813867
RX   PubMed=11121133;
RX   PubMed=11851879;
RX   PubMed=18384130;
RX   PubMed=19799798;
RX   PubMed=21424129;
RX   PubMed=29492214;
CC   Microsatellite instability: Stable (MSS) (PubMed=11851879).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=19799798; PubMed=29492214).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 15
//
RX   PubMed=11121133; DOI=10.1046/j.1523-1747.2000.00199.x;
RA   Lacal P.M., Failla C.M., Pagani E., Odorisio T., Schietroma C.,
RA   Falcinelli S., Zambruno G., D'Atri S.;
RT   "Human melanoma cells secrete and respond to placenta growth factor
RT   and vascular endothelial growth factor.";
RL   J. Invest. Dermatol. 115:1000-1007(2000).
//
RX   PubMed=11851879; DOI=10.1046/j.0022-202x.2001.01611.x;
RA   Alvino E., Marra G., Pagani E., Falcinelli S., Pepponi R., Perrera C.,
RA   Haider R., Castiglia D., Ferranti G., Bonmassar E., Jiricny J.,
RA   Zambruno G., D'Atri S.;
RT   "High-frequency microsatellite instability is associated with
RT   defective DNA mismatch repair in human melanoma.";
RL   J. Invest. Dermatol. 118:79-86(2002).
//
RX   PubMed=18384130; DOI=10.1002/gcc.20567;
RA   Castiglia D., Bernardini S., Alvino E., Pagani E., De Luca N.,
RA   Falcinelli S., Pacchiarotti A., Bonmassar E., Zambruno G., D'Atri S.;
RT   "Concomitant activation of Wnt pathway and loss of mismatch repair
RT   function in human melanoma.";
RL   Genes Chromosomes Cancer 47:614-624(2008).
//
RX   PubMed=19799798; DOI=10.1186/1471-2407-9-352; PMCID=PMC2763007;
RA   Casula M., Muggiano A., Cossu A., Budroni M., Caraco C.,
RA   Ascierto P.A., Pagani E., Stanganelli I., Canzanella S., Sini M.C.,
RA   Palomba G., Palmieri G.;
RG   Italian Melanoma Intergroup (IMI);
RT   "Role of key-regulator genes in melanoma susceptibility and
RT   pathogenesis among patients from South Italy.";
RL   BMC Cancer 9:352.1-352.11(2009).
//
RX   PubMed=21424129; DOI=10.3892/or.2011.1220;
RA   Manca A., Sini M.C., Izzo F., Ascierto P.A., Tatangelo F., Botti G.,
RA   Gentilcore G., Capone M., Mozzillo N., Rozzo C., Cossu A., Tanda F.,
RA   Palmieri G.;
RT   "Induction of arginosuccinate synthetase (ASS) expression affects the
RT   antiproliferative activity of arginine deiminase (ADI) in melanoma
RT   cells.";
RL   Oncol. Rep. 25:1495-1502(2011).
//
RX   PubMed=29492214; DOI=10.18632/oncotarget.23989; PMCID=PMC5823576;
RA   Sini M.C., Doneddu V., Paliogiannis P., Casula M., Colombino M.,
RA   Manca A., Botti G., Ascierto P.A., Lissia A., Cossu A., Palmieri G.;
RT   "Genetic alterations in main candidate genes during melanoma
RT   progression.";
RL   Oncotarget 9:8531-8541(2018).
//