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Cellosaurus BL-60 (CVCL_7034)

[Text version]
Cell line name BL-60
Synonyms BL60; BL 60; BL 060; IARC/BL60; IARC/BL 60; IARC-BL60; IARC BL60; IARC BL 60
Accession CVCL_7034
Resource Identification Initiative To cite this cell line use: BL-60 (RRID:CVCL_7034)
Comments From: International Agency of Research on Cancer (IARC); Lyon; France.
Population: Algerian.
Virology: Contains an integrated EBV genome (PubMed=8382295).
Doubling time: ~48 hours (DSMZ=ACC-953).
Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
Derived from site: In situ; Bone, jaw; UBERON=UBERON_0001708.
Cell type: B-cell; CL=CL_0000236.
Sequence variations
Disease EBV-related Burkitt lymphoma (NCIt: C27694)
Burkitt lymphoma (ORDO: Orphanet_543)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_IV17 ! IARC-261
CVCL_IV06 ! IARC-277
Sex of cell Female
Age at sampling 4Y
Category Cancer cell line
STR profile Source(s): DSMZ=ACC-953

Markers:
AmelogeninX
CSF1PO10,11
D2S133818,20
D3S135815,17
D5S81810,12
D7S82011,12
D8S117910,15
D13S31712,14
D16S53910,11
D18S5111,12
D19S43314,15
D21S1129,31
FGA24,26
Penta D11,13
Penta E11,13
TH016,9
TPOX9,11
vWA16,17

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Publications

PubMed=6087353; DOI=10.1073/pnas.81.15.4930; PMCID=PMC391606
Georg-Wilhelm Bornkamm, Magnus von Knebel-Doeberitz, Gilbert Marcel Lenoir;
No evidence for differences in the Epstein-Barr virus genome carried in Burkitt lymphoma cells and nonmalignant lymphoblastoid cells from the same patients.
Proc. Natl. Acad. Sci. U.S.A. 81:4930-4934(1984)

PubMed=2985508; DOI=10.1002/ijc.2910350404
Martin Rowe, Cliona M. Rooney, Alan Bernard Rickinson, Gilbert Marcel Lenoir, Hitesh Rupani, Denis J. Moss, Harald Stein, Michael Anthony Epstein;
Distinctions between endemic and sporadic forms of Epstein-Barr virus-positive Burkitt's lymphoma.
Int. J. Cancer 35:435-441(1985)

PubMed=3934070
Gilbert Marcel Lenoir, Michele Vuillaume, Colette Bonnardel;
The use of lymphomatous and lymphoblastoid cell lines in the study of Burkitt's lymphoma.
IARC Sci. Publ. 60:309-318(1985)

PubMed=3026973; DOI=10.1002/ijc.2910390215
Barbro Ehlin-Henriksson, Agneta Manneborg-Sandlund, George Klein;
Expression of B-cell-specific markers in different Burkitt lymphoma subgroups.
Int. J. Cancer 39:211-218(1987)

PubMed=3027441; DOI=10.1093/jnci/78.2.235
Jacques H.M. Cohen, Jean-Pierre Revillard, Jean-Pierre Magaud, Gilbert Marcel Lenoir, Michele Vuillaume, Anne-Marie Manel, Claude Vincent, Paul-Andre Bryon;
B-cell maturation stages of Burkitt's lymphoma cell lines according to Epstein-Barr virus status and type of chromosome translocation.
J. Natl. Cancer Inst. 78:235-242(1987)

PubMed=3035497; DOI=10.1093/nar/15.11.4553; PMCID=PMC340879
Marie-France Szajnert, Simon Saule, Georg-Wilhelm Bornkamm, Henri Wajcman, Gilbert Marcel Lenoir, Jean-Claude Kaplan;
Clustered somatic mutations in and around first exon of non-rearranged c-myc in Burkitt lymphoma with t(8;22) translocation.
Nucleic Acids Res. 15:4553-4565(1987)

PubMed=2898508; DOI=10.1084/jem.167.6.1811; PMCID=PMC2189677
Christopher D. Gregory, Ruth J. Murray, Carole F. Edwards, Alan Bernard Rickinson;
Downregulation of cell adhesion molecules LFA-3 and ICAM-1 in Epstein-Barr virus-positive Burkitt's lymphoma underlies tumor cell escape from virus-specific T cell surveillance.
J. Exp. Med. 167:1811-1824(1988)

PubMed=1945409
Axel Polack, Lothar J. Strobl, Regina Feederle, Matthias Schweizer, Erika Koch, Dirk Eick, Helga Wiegand, Georg-Wilhelm Bornkamm;
The intron enhancer of the immunoglobulin kappa gene activates c-myc but does not induce the Burkitt-specific promoter shift.
Oncogene 6:2033-2040(1991)

PubMed=2052620; DOI=10.1073/pnas.88.12.5413; PMCID=PMC51883
Gianluca Gaidano, Paola Ballerini, Jerry Z. Gong, Giorgio Inghirami, Antonino Neri, Elizabeth W. Newcomb, Ian Trevor Magrath, Daniel M. Knowles, Riccardo Dalla-Favera;
p53 mutations in human lymphoid malignancies: association with Burkitt lymphoma and chronic lymphocytic leukemia.
Proc. Natl. Acad. Sci. U.S.A. 88:5413-5417(1991)

PubMed=1356511; DOI=10.1182/blood.V80.7.1781.1781
Gianluca Gaidano, Robert S. Hauptschein, Nasser Z. Parsa, Kenneth Offit, Pulivarthi H. Rao, Gilbert Marcel Lenoir, Daniel M. Knowles, Raju S.K. Chaganti, Riccardo Dalla-Favera;
Deletions involving two distinct regions of 6q in B-cell non-Hodgkin lymphoma.
Blood 80:1781-1787(1992)

PubMed=8382295; DOI=10.1128/JVI.67.3.1292-1299.1993; PMCID=PMC237496
Henri-Jacques Delecluse, Sabine Bartnitzke, Wolfgang Hammerschmidt, Jorn Bullerdiek, Georg-Wilhelm Bornkamm;
Episomal and integrated copies of Epstein-Barr virus coexist in Burkitt lymphoma cell lines.
J. Virol. 67:1292-1299(1993)

PubMed=7519050; DOI=10.1002/gcc.2870090408
Reinhard Zeidler, Stefan Joos, Henri-Jacques Delecluse, Hans-Gustav Klobeck, Michele Vuillaume, Gilbert Marcel Lenoir, Georg-Wilhelm Bornkamm, Martin Lipp;
Breakpoints of Burkitt's lymphoma t(8;22) translocations map within a distance of 300 kb downstream of MYC.
Genes Chromosomes Cancer 9:282-287(1994)

PubMed=9473234; DOI=10.1182/blood.V91.5.1680
Ulf Klangby, Ismail Okan, Kristinn Petur Magnusson, Martin Wendland, Peter Lind, Klas G. Wiman;
p16/INK4a and p15/INK4b gene methylation and absence of p16/INK4a mRNA and protein expression in Burkitt's lymphoma.
Blood 91:1680-1687(1998)

PubMed=10997876; DOI=10.1093/dnares/7.4.261
Robert S. Hauptschein, Gianluca Gaidano, Pulivarthi H. Rao, Luigi Scotto, Yvonne H. Edwards, Raju S.K. Chaganti, Riccardo Dalla-Favera;
An apparent interlocus gene conversion-like event at a putative tumor suppressor gene locus on human chromosome 6q27 in a Burkitt's lymphoma cell line.
DNA Res. 7:261-272(2000)

PubMed=11793449; DOI=10.1002/gcc.10022
Hagay Sobol, Athmane Benziane, Fabienne Kerangueven, Luo Yin, Tetsuro Noguchi, Suzanne Pauly, Francois Eisinger, Michel Longy, Giovanni Romeo, Gilbert Marcel Lenoir, Daniel Birnbaum;
Genome-wide search for loss of heterozygosity in Burkitt lymphoma cell lines.
Genes Chromosomes Cancer 33:217-224(2002)

PubMed=19358282; DOI=10.1002/ijc.24351
Atsushi Inagaki, Takashi Ishida, Hiroki Yano, Toshihiko Ishii, Shigeru Kusumoto, Asahi Ito, Masaki Ri, Fumiko Mori, Jian-Min Ding, Hirokazu Komatsu, Shinsuke Iida, Ryuzo Ueda;
Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC.
Int. J. Cancer 125:212-221(2009)

PubMed=24590883; DOI=10.1002/gcc.22161
Eva-Maria Murga Penas, Georgia Schilling, Petra Behrmann, Marianne Klokow, Eik Vettorazzi, Carsten Bokemeyer, Judith Dierlamm;
Comprehensive cytogenetic and molecular cytogenetic analysis of 44 Burkitt lymphoma cell lines: secondary chromosomal changes characterization, karyotypic evolution, and comparison with primary samples.
Genes Chromosomes Cancer 53:497-515(2014)

Cross-references
Cell line collections (Providers) DSMZ; ACC-953
Cell line databases/resources cancercelllines; CVCL_7034
Anatomy/cell type resources BTO; BTO_0001934
Encyclopedic resources Wikidata; Q54797225
Experimental variables resources EFO; EFO_0022349
Polymorphism and mutation databases Cosmic; 931100
IARC_TP53; 137
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number26