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Cellosaurus IIICF-T/B1 (CVCL_6F12)

[Text version]
Cell line name IIICF-T/B1
Synonyms LTAG-transformed IIICF clone B1
Accession CVCL_6F12
Resource Identification Initiative To cite this cell line use: IIICF-T/B1 (RRID:CVCL_6F12)
Comments Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=pRSV-T).
Derived from site: In situ; Breast, stroma; UBERON=UBERON_0003584.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Thr125Thr (c.375G>A); ClinVar=VCV000177825; Zygosity=Hemizygous; Note=Impairs TP53 splicing dramatically (from parent cell line).
Disease Li-Fraumeni syndrome (NCIt: C3476)
Li-Fraumeni syndrome (ORDO: Orphanet_524)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_4415 (IIICF/c)
Sex of cell Female
Age at sampling 30-40Y
Category Transformed cell line
Publications

PubMed=8108114
MacLean K., Rogan E.M., Whitaker N.J., Chang A.C.-M., Rowe P.B., Dalla-Pozza L., Symonds G., Reddel R.R.
In vitro transformation of Li-Fraumeni syndrome fibroblasts by SV40 large T antigen mutants.
Oncogene 9:719-725(1994)

PubMed=9175740; DOI=10.1093/hmg/6.6.921
Bryan T.M., Marusic L., Bacchetti S., Namba M., Reddel R.R.
The telomere lengthening mechanism in telomerase-negative immortal human cells does not involve the telomerase RNA subunit.
Hum. Mol. Genet. 6:921-926(1997)

Cross-references
Encyclopedic resources Wikidata; Q54897431
Entry history
Entry creation23-Feb-2016
Last entry update10-Sep-2024
Version number12