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Cellosaurus BEP2D (CVCL_6E77)

[Text version]
Cell line name BEP2D
Accession CVCL_6E77
Resource Identification Initiative To cite this cell line use: BEP2D (RRID:CVCL_6E77)
Comments Doubling time: 35 hours (PubMed=8118924).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Lung, bronchus, epithelium; UBERON=UBERON_0002031.
Cell type: Epithelial cell of bronchus; CL=CL_0002328.
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B4IS (BEP2D Fe60T1)CVCL_B4IT (BEP2D Fe60T2)CVCL_B4IU (BEP2D Fe60T3)
CVCL_B4IV (BEP2D Fe60T4)CVCL_B4IW (BEP2D H1A)CVCL_B4IZ (BEP2D H1B)
CVCL_B4J0 (BEP2D H2B)CVCL_B4J4 (BEP2D H3A)CVCL_6E79 (BEP2D R15H)
CVCL_B4J5 (BEP2D R2D6)CVCL_B4J6 (BEP2D R30)CVCL_B4JB (BEP2D R3D7)
CVCL_B4JC (BEP2D R5D7)
Originate from same individual CVCL_B4IR ! BEP1B
CVCL_6E78 ! BEP3D
Sex of cell Male
Age at sampling Age unspecified
Category Transformed cell line
STR profile Source(s): PubMed=31158229

Markers:
AmelogeninX,Y
CSF1PO9,12
D1S165614
D2S44111,11.3
D2S133822,23
D3S135815,17
D5S81812,13
D6S104312,18
D7S82010,13
D8S117913,15
D10S124814,15
D12S39117,18
D13S31713
D16S53912
D18S5118,19
D19S43313.2,15.2
D21S1128,30
D22S104514,16
DYS39110
FGA20,24
Penta D2.2,13
Penta E5,8
SE3320.2,28.2
TH017,9.3
TPOX6,11
vWA17,18

Run an STR similarity search on this cell line
Publications

DOI=10.1007/978-1-4612-0411-4_11
Willey J.C., Greene J., Bressoud A., Cerutti P.A., Hei T.K., Wang N., Maillie D., Cox C., Miles E.
Effects of ionizing radiation on human papillomavirus immortalized human bronchial epithelial cells.
(In book chapter) Neoplastic transformation in human cell system. Mechanism of carcinogenesis; Rhim J.S., Dritschilo A. (eds.); pp.113-117; Humana Press; New York; USA (1990)

PubMed=1717149
Willey J.C., Bressoud A., Sleemi A., Bennett W.P., Cerutti P.A., Harris C.C.
Immortalization of normal human bronchial epithelial cells by human papillomaviruses 16 or 18.
Cancer Res. 51:5370-5377(1991)

PubMed=8118924; DOI=10.1093/carcin/15.3.431
Hei T.K., Piao C.Q., Willey J.C., Sutter T., Hall E.J.
Malignant transformation of human bronchial epithelial cells by radon-simulated alpha-particles.
Carcinogenesis 15:431-437(1994)

PubMed=11538954; DOI=10.1016/0273-1177(95)00800-t
Hei T.K., Piao C.Q., Sutter T., Willey J.C., Suzuki K.
Cellular and molecular alterations in human epithelial cells transformed by high LET radiation.
Adv. Space Res. 18:137-148(1996)

PubMed=9214610; DOI=10.1093/carcin/18.6.1251
Weaver D.A., Hei T.K., Hukku B., McRaven J.A., Willey J.C.
Cytogenetic and molecular genetic analysis of tumorigenic human bronchial epithelial cells induced by radon alpha particles.
Carcinogenesis 18:1251-1257(1997)

PubMed=10426802; DOI=10.1093/carcin/20.8.1529
Piao C.Q., Willey J.C., Hei T.K.
Alterations of p53 in tumorigenic human bronchial epithelial cells correlate with metastatic potential.
Carcinogenesis 20:1529-1533(1999)

PubMed=10657959; DOI=10.1093/carcin/21.2.205
Weaver D.A., Hei T.K., Hukku B., DeMuth J.P., Crawford E.L., McRaven J.A., Girgis S., Willey J.C.
Localization of tumor suppressor gene candidates by cytogenetic and short tandem repeat analyses in tumorigenic human bronchial epithelial cells.
Carcinogenesis 21:205-211(2000)

DOI=10.3760/cma.j.issn.0254-5098.2003.04.001
Fan B.-X., Zhang K.-T., Sun J.-F., Xiang X.-Q., Xie L., Hu Y.-C., Wang S.-Q., Wu D.-C.
Identification of differentially expressed genes in different malignant transformation phases of BEP2D cell line.
Zhonghua Fang She Yi Xue Yu Fang Hu Za Zhi 23:231-233(2003)

PubMed=12548635; DOI=10.1002/pmic.200390010
Ying W.-T., Zhang K.-T., Qian X.-H., Xie L., Wang J., Xiang X.-Q., Cai Y., Wu D.-C.
Proteome analysis on an early transformed human bronchial epithelial cell line, BEP2D, after alpha-particle irradiation.
Proteomics 3:64-72(2003)

PubMed=24944801; DOI=10.3892/br.2014.268; PMCID=PMC4051483
Liu C.-Y., Li P., Gao D.-W., Zhou P.-K., Shao Y., Zhang Q., Li W.-B.
Abnormal promoter methylation of multiple tumor suppressor genes in human bronchial epithelial malignant cells.
Biomed. Rep. 2:525-528(2014)

PubMed=31158229; DOI=10.1371/journal.pone.0213047; PMCID=PMC6546236
Liu Q.-W., Li H., You L.-K., Li T., Li L.-L., Zhou P.-K., Bo X.-C., Chen H.-B., Chen X.-H., Hu Y.
Genome-wide identification and analysis of A-to-I RNA editing events in the malignantly transformed cell lines from bronchial epithelial cell line induced by alpha-particles radiation.
PLoS ONE 14:E0213047-E0213047(2019)

Cross-references
Encyclopedic resources Wikidata; Q54796049
Gene expression databases GEO; GSM3611827
GEO; GSM3611828
GEO; GSM3611829
Entry history
Entry creation23-Feb-2016
Last entry update05-Oct-2023
Version number9