ID   T2-A
AC   CVCL_6C58
DR   Wikidata; Q54971431
RX   PubMed=26254261;
CC   Characteristics: Obtained by intravenous injection of parent cell line (T1-A) in the tail vein of NIH Swiss mice and selection of cells from a local metastasis.
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
CC   Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
CC   Cell type: Fibroblast; CL=CL_0000057.
CC   Breed/subspecies: NIH Swiss.
OX   NCBI_TaxID=10090; ! Mus musculus (Mouse)
HI   CVCL_6C57 ! T1-A
SX   Male
AG   Embryo
CA   Transformed cell line
DT   Created: 23-02-16; Last updated: 19-12-24; Version: 10
//
RX   PubMed=26254261; DOI=10.1016/j.yexcr.2015.07.029;
RA   Ray D.B., Merrill G.A., Brenner F.J., Lytle L.S., Lam T.,
RA   McElhinney A., Anders J., Rock T.T., Lyker J.K., Barcus S.,
RA   Leslie K.H., Kramer J.M., Rubenstein E.M., Pryor Schanz K.,
RA   Parkhurst A.J., Peck M., Good K., Granath K.L., Cifra N.,
RA   Detweiler J.W., Stevens L., Albertson R., Deir R., Stewart E.,
RA   Wingard K., Richardson M.R., Blizard S.B., Gillespie L.E.,
RA   Kriley C.E., Rzewnicki D.I., Jones D.H.;
RT   "T24 HRAS transformed NIH/3T3 mouse cells (GhrasT-NIH/3T3) in serial
RT   tumorigenic in vitro/in vivo passages give rise to increasingly
RT   aggressive tumorigenic cell lines T1-A and T2-A and metastatic cell
RT   lines T3-HA and T4-PA.";
RL   Exp. Cell Res. 340:1-11(2016).
//