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Cellosaurus T1-A (CVCL_6C57)

[Text version]
Cell line name T1-A
Accession CVCL_6C57
Resource Identification Initiative To cite this cell line use: T1-A (RRID:CVCL_6C57)
Comments Characteristics: Highly tumorigenic. Obtained by subcutaneous hind quarter injection of parent cell line (GhrasT-NIH/3T3) in NIH Swiss mice and selection of cells from a hind quarter tumor.
Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:5173; HRAS (Note=With p.Gly12Val).
Derived from site: In situ; Whole embryo; UBERON=UBERON_0000922.
Cell type: Fibroblast; CL=CL_0000057.
Species of origin Mus musculus (Mouse) (NCBI Taxonomy: 10090)
Breed/subspecies: NIH Swiss.
Hierarchy Parent: CVCL_WS34 (GhrasT-NIH/Swiss)
Children:
CVCL_6C58 (T2-A)
Sex of cell Male
Age at sampling Embryo
Category Transformed cell line
Publications

PubMed=26254261; DOI=10.1016/j.yexcr.2015.07.029
Ray D.B., Merrill G.A., Brenner F.J., Lytle L.S., Lam T., McElhinney A., Anders J., Rock T.T., Lyker J.K., Barcus S., Leslie K.H., Kramer J.M., Rubenstein E.M., Pryor Schanz K., Parkhurst A.J., Peck M., Good K., Granath K.L., Cifra N., Detweiler J.W., Stevens L., Albertson R., Deir R., Stewart E., Wingard K., Richardson M.R., Blizard S.B., Gillespie L.E., Kriley C.E., Rzewnicki D.I., Jones D.H.
T24 HRAS transformed NIH/3T3 mouse cells (GhrasT-NIH/3T3) in serial tumorigenic in vitro/in vivo passages give rise to increasingly aggressive tumorigenic cell lines T1-A and T2-A and metastatic cell lines T3-HA and T4-PA.
Exp. Cell Res. 340:1-11(2016)

Cross-references
Encyclopedic resources Wikidata; Q54971396
Entry history
Entry creation23-Feb-2016
Last entry update19-Dec-2024
Version number10