Cellosaurus cell line PDL-L2 (CVCL

Cellosaurus PDL-L2 (CVCL_6B13)

Cross-references
Cell line name	PDL-L2
Synonyms	PDL-L 2
Accession	CVCL_6B13
Resource Identification Initiative	To cite this cell line use: PDL-L2 (RRID:CVCL_6B13)
Comments	Genetic integration: Method=Transgenic mouse; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58). Omics: Transcriptomics; Microarray. Derived from site: In situ; Tooth, periodontal ligament; UBERON=UBERON_0008266. Cell type: Fibroblast of periodontal ligament; CL=CL_2000017.
Species of origin	Mus musculus (Mouse) (NCBI Taxonomy: 10090) Breed/subspecies: C57BL/6 SV40-tsA58 transgenic.
Sex of cell	Sex unspecified
Age at sampling	5W
Category	Conditionally immortalized cell line
Publications	PubMed=12356921; DOI=10.1242/jcs.00098 Yoshinori Saito, Tatsuya Yoshizawa, Fumio Takizawa, Mika Ikegame, Osamu Ishibashi, Kazuhiro Okuda, Kohji Hara, Kotaro Ishibashi, Masuo Obinata, Hiroyuki Kawashima; A cell line with characteristics of the periodontal ligament fibroblasts is negatively regulated for mineralization and Runx2/Cbfa1/Osf2 activity, part of which can be overcome by bone morphogenetic protein-2. J. Cell Sci. 115:4191-4200(2002) PubMed=17233813; DOI=10.1111/j.1349-7006.2007.00399.x; PMCID=PMC11159456 Masuo Obinata; The immortalized cell lines with differentiation potentials: their establishment and possible application. Cancer Sci. 98:275-283(2007) PubMed=24949082; DOI=10.1186/1750-2187-9-5; PMCID=PMC4062770 Osamu Ishibashi, Takashi Inui; Identification of endoglin-dependent BMP-2-induced genes in the murine periodontal ligament cell line PDL-L2. J. Mol. Signal. 9:5.1-5.6(2014)
Encyclopedic resources	Wikidata; Q54946852
Entry history
Entry creation	23-Feb-2016
Last entry update	14-Aug-2025
Version number	12