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Cellosaurus OCM-8 (CVCL_6938)

[Text version]
Cell line name OCM-8
Synonyms OCM8; Ocm8; ocm-8
Accession CVCL_6938
Resource Identification Initiative To cite this cell line use: OCM-8 (RRID:CVCL_6938)
Comments Problematic cell line: Contaminated. Shown to be a SK-MEL-28 derivative (PubMed=22236444 and STR profile from PubMed=18689700). Originally thought to originate from an uveal melanoma.
From: Kan-Mitchell J.; Wayne State University; Detroit; USA.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00504.
Population: Caucasian.
Derived from site: In situ; Skin; UBERON=UBERON_0002097.
Cell type: Melanocyte of skin; CL=CL_1000458.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (PubMed=22236444).
  • Mutation; HGNC; 1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 3236; EGFR; Simple; p.Pro753Ser (c.2257C>T); ClinVar=VCV000376081; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 9588; PTEN; Simple; p.Thr167Ala (c.499A>G); ClinVar=VCV001686107; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.-57A>C (c.161A>C) (A161C); ClinVar=VCV000242210; Zygosity=Unspecified; Note=In promoter (from parent cell line).
  • Mutation; HGNC; 11998; TP53; Simple; p.Leu145Arg (c.434T>G); ClinVar=VCV001027110; Zygosity=Homozygous (from parent cell line).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0526 (SK-MEL-28)
Sex of cell Male
Age at sampling 51Y
Category Cancer cell line
STR profile Source(s): ESTDAB; PubMed=18689700


Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx

PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016
White J.S., Becker R.L., McLean I.W., Director-Myska A.E., Nath J.
Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.
Cancer Genet. Cytogenet. 168:11-21(2006)

PubMed=18689700; DOI=10.1167/iovs.08-2324
Folberg R., Kadkol S.S., Frenkel S., Valyi-Nagy K., Jager M.J., Pe'er J., Maniotis A.J.
Authenticating cell lines in ophthalmic research laboratories.
Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008)

PubMed=19340423; DOI=10.1007/s00262-009-0701-z
Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello F., Garrido F., Garcia-Lora A.
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x
Griewank K.G., Yu X.-X., Khalili J., Sozen M.M., Stempke-Hale K., Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.
Genetic and molecular characterization of uveal melanoma cell lines.
Pigment Cell Melanoma Res. 25:182-187(2012)

PubMed=23849826; DOI=10.1016/j.ejca.2013.06.011
Amaro A., Mirisola V., Angelini G., Musso A., Tosetti F.I., Esposito A.I., Perri P., Lanza F.B., Nasciuti F., Mosci C., Puzone R., Salvi S., Truini M., Poggi A., Pfeffer U.
Evidence of epidermal growth factor receptor expression in uveal melanoma: inhibition of epidermal growth factor-mediated signalling by Gefitinib and Cetuximab triggered antibody-dependent cellular cytotoxicity.
Eur. J. Cancer 49:3353-3365(2013)

Cell line databases/resources cancercelllines; CVCL_6938
Biological sample resources BioSample; SAMN06481120
Encyclopedic resources Wikidata; Q54931810
Polymorphism and mutation databases Cosmic; 1320370
Cosmic; 1628410
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number31