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Cellosaurus OCM-1A (CVCL_6935)

[Text version]
Cell line name OCM-1A
Synonyms OCM1A; OCM1a
Accession CVCL_6935
Resource Identification Initiative To cite this cell line use: OCM-1A (RRID:CVCL_6935)
Comments Problematic cell line: Contaminated. Parent cell line (OCM-1) has been shown to be a M14 derivative.
Population: Caucasian.
Miscellaneous: Formerly the CCRID database had an entry describing this cell line (3111C0001CCC000234). It was one of the sources for the STR profile of this entry.
Derived from site: Metastatic; Right buttock, hypodermis; UBERON=UBERON_0013691+UBERON_0002072.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6934 (OCM-1)
Sex of cell Male
Age at sampling 33Y
Category Cancer cell line
STR profile Source(s): CCRID

Markers:
AmelogeninX
CSF1PO11
D2S133819
D3S135814,16
D5S81811,12
D7S8208,10
D8S117913
D13S31712
D16S5399
D18S5113,18
D19S43314,15
D21S1130
FGA21
TH016,7
TPOX8,11
vWA18

Run an STR similarity search on this cell line
Publications

PubMed=15299072; DOI=10.1158/1535-7163.895.3.8
Qin J.-Z., Stennett L., Bacon P., Bodner B., Hendrix M.J.C., Seftor R.E.B., Seftor E.A., Margaryan N.V., Pollock P.M., Curtis A., Trent J.M., Bennett F., Miele L., Nickoloff B.J.
p53-independent NOXA induction overcomes apoptotic resistance of malignant melanomas.
Mol. Cancer Ther. 3:895-902(2004)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6935
Encyclopedic resources Wikidata; Q54931806
Gene expression databases GEO; GSM1082693
Polymorphism and mutation databases Cosmic; 1247863
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number22