ID   OCM-1
AC   CVCL_6934
SY   OCM1; Ocm1; Ocular Choroidal Melanoma-1
DR   BTO; BTO:0002736
DR   Cosmic; 848327
DR   Cosmic; 899892
DR   Cosmic; 916139
DR   Cosmic; 986617
DR   Cosmic; 1320368
DR   Cosmic; 1628408
DR   GEO; GSM276733
DR   Wikidata; Q54931805
RX   PubMed=2722439;
RX   PubMed=8621261;
RX   PubMed=9154388;
RX   PubMed=15714118;
RX   PubMed=16772116;
RX   PubMed=17487557;
RX   PubMed=18689700;
RX   PubMed=22236444;
RX   PubMed=28940260;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a M14 derivative (PubMed=28940260). Originally thought to originate from a female patient with uveal melanoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00502.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=22236444).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.150+2T>C (IVS1+2T>C); ClinVar=VCV000406712; Zygosity=Heterozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; c.455insCdel26; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Gly266Glu (c.797G>A); ClinVar=VCV000161516; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from metastatic site: Right buttock; hypodermis.
ST   Source(s): PubMed=18689700
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 12
ST   D16S539: 9
ST   D18S51: 13,18
ST   D21S11: 30
ST   D3S1358: 14,16
ST   D5S818: 11,12
ST   D7S820: 8,10
ST   D8S1179: 13
ST   FGA: 21
ST   TH01: 6,7
ST   TPOX: 8,11
ST   vWA: 18
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1395 ! M14
SX   Male
AG   33Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 21-03-23; Version: 26
//
RX   PubMed=2722439;
RA   Kan-Mitchell J., Mitchell M.S., Rao N., Liggett P.E.;
RT   "Characterization of uveal melanoma cell lines that grow as xenografts
RT   in rabbit eyes.";
RL   Invest. Ophthalmol. Vis. Sci. 30:829-834(1989).
//
RX   PubMed=8621261; DOI=10.1002/(SICI)1097-0215(19960503)66:3<380::AID-IJC19>3.0.CO;2-F;
RA   Luyten G.P.M., Naus N.C., Mooy C.M., Hagemeijer A., Kan-Mitchell J.,
RA   van Drunen E., Vuzevski V., de Jong P.T.V.M., Luider T.M.;
RT   "Establishment and characterization of primary and metastatic uveal
RT   melanoma cell lines.";
RL   Int. J. Cancer 66:380-387(1996).
//
RX   PubMed=9154388; DOI=10.1076/ceyr.16.5.487.7047;
RA   Diebold Y., Blanco G., Saornil M.A., Fernandez N., Lazaro M.C.;
RT   "Morphologic and immunocytochemical characterization of four human
RT   uveal cell lines (melanoma- and melanocytes-derived).";
RL   Curr. Eye Res. 16:487-495(1997).
//
RX   PubMed=15714118; DOI=10.1097/00008390-200502000-00006;
RA   Lopez-Velasco R., Morilla-Grasa A., Saornil-Alvarez M.A.,
RA   Ordonez J.L., Blanco G., Rabano G., Fernandez N., Almaraz A.;
RT   "Efficacy of five human melanocytic cell lines in experimental rabbit
RT   choroidal melanoma.";
RL   Melanoma Res. 15:29-37(2005).
//
RX   PubMed=16772116; DOI=10.1016/j.cancergencyto.2005.11.016;
RA   White J.S., Becker R.L., McLean I.W., Director-Myska A.E., Nath J.;
RT   "Molecular cytogenetic evaluation of 10 uveal melanoma cell lines.";
RL   Cancer Genet. Cytogenet. 168:11-21(2006).
//
RX   PubMed=17487557; DOI=10.1007/s10585-007-9072-z;
RA   Marshall J.-C., Nantel A., Blanco P., Ash J., Cruess S.R.,
RA   Burnier M.N. Jr.;
RT   "Transcriptional profiling of human uveal melanoma from cell lines to
RT   intraocular tumors to metastasis.";
RL   Clin. Exp. Metastasis 24:353-362(2007).
//
RX   PubMed=18689700; DOI=10.1167/iovs.08-2324;
RA   Folberg R., Kadkol S.S., Frenkel S., Valyi-Nagy K., Jager M.J.,
RA   Pe'er J., Maniotis A.J.;
RT   "Authenticating cell lines in ophthalmic research laboratories.";
RL   Invest. Ophthalmol. Vis. Sci. 49:4697-4701(2008).
//
RX   PubMed=22236444; DOI=10.1111/j.1755-148X.2012.00971.x;
RA   Griewank K.G., Yu X., Khalili J., Sozen M.M., Stempke-Hale K.,
RA   Bernatchez C., Wardell S., Bastian B.C., Woodman S.E.;
RT   "Genetic and molecular characterization of uveal melanoma cell
RT   lines.";
RL   Pigment Cell Melanoma Res. 25:182-187(2012).
//
RX   PubMed=28940260; DOI=10.1002/ijc.31067;
RA   Korch C.T., Hall E.M., Dirks W.G., Ewing M., Faries M., Varella-Garcia M.,
RA   Robinson S., Storts D.R., Turner J.A., Wang Y., Burnett E.C.,
RA   Healy L.E., Kniss D.A., Neve R.M., Nims R.W., Reid Y.A., Robinson W.A.,
RA   Capes-Davis A.;
RT   "Authentication of M14 melanoma cell line proves misidentification of
RT   MDA-MB-435 breast cancer cell line.";
RL   Int. J. Cancer 142:561-572(2017).
//