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Cellosaurus L-02 (CVCL_6926)

[Text version]
Cell line name L-02
Synonyms L02; LO2; HL-7702; HL7702; Liver-02; Human Liver-7702
Accession CVCL_6926
Resource Identification Initiative To cite this cell line use: L-02 (RRID:CVCL_6926)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=26116706). Originally thought to originate from a normal fetal liver.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00575.
Population: African American.
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: Proteome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_WN40 (HL-7702BaPT)CVCL_E0X3 (Ubigene L-02 ACSL4 KO)CVCL_E0X4 (Ubigene L-02 EIF2AK4 KO)
CVCL_E0X5 (Ubigene L-02 HIF1A KO)CVCL_E0X6 (Ubigene L-02 OLA1 KO)CVCL_E0X7 (Ubigene L-02 TFEB KO)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): PubMed=26116706

Markers:
AmelogeninX
CSF1PO10
D3S135815,18
D5S81811,12
D7S82012
D8S117912
D13S31713.3
D16S5399,10
D18S5116
D21S1127,28
FGA18,21
Penta D8,15
Penta E7,17
TH017
TPOX12
vWA16,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
http://www.roche-applied-science.com/wcsstore/RASCatalogAssetStore/Articles/CustomerProtocol_X-tremeGENE%20HP_L02.pdf
https://www.quora.com/How-does-the-L-02-cell-line-compare-with-the-TAMH-cell-line-How-closely-do-these-two-cell-lines-resemble-actual-human-hepatocytes
Publications

PubMed=23498809; DOI=10.1016/j.transproceed.2012.09.121
Hu X., Yang T., Li C., Zhang L., Li M., Huang W., Zhou P.
Human fetal hepatocyte line, L-02, exhibits good liver function in vitro and in an acute liver failure model.
Transplant. Proc. 45:695-700(2013)

PubMed=23505090; DOI=10.1002/hep.26402
Wang K., Lim H.Y., Shi S., Lee J., Deng S.-B., Xie T., Zhu Z., Wang Y.-L., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.-C.
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=26116706; DOI=10.1096/fj.14-266718
Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.
Genetic profiling reveals an alarming rate of cross-contamination among human cell lines used in China.
FASEB J. 29:4268-4272(2015)

PubMed=26143199; DOI=10.1016/j.jhazmat.2015.06.031
Cui R.-N., Zhang H.-X., Guo X.-J., Cui Q.-Q., Wang J.-S., Dai J.-Y.
Proteomic analysis of cell proliferation in a human hepatic cell line (HL-7702) induced by perfluorooctane sulfonate using iTRAQ.
J. Hazard. Mater. 299:361-370(2015)

PubMed=27027780; DOI=10.1007/s10565-016-9316-2
Wu Y., Geng X.-C., Wang J.-F., Miao Y.-F., Lu Y.-L., Li B.
The HepaRG cell line, a superior in vitro model to L-02, HepG2 and hiHeps cell lines for assessing drug-induced liver injury.
Cell Biol. Toxicol. 32:37-59(2016)

Cross-references
Cell line collections (Providers) KCB; KCB 200511YJ
Ubigene; YC-D004
Cell line databases/resources TOKU-E; 3606
Anatomy/cell type resources BTO; BTO_0005965
Chemistry resources ChEMBL-Cells; CHEMBL4295475
ChEMBL-Targets; CHEMBL4296457
PubChem_Cell_line; CVCL_6926
Encyclopedic resources Wikidata; Q54900854
Gene expression databases GEO; GSM936770
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number23