ID   KOCL-50
AC   CVCL_6866
SY   KOCL50
DR   cancercelllines; CVCL_6866
DR   Cosmic; 1037748
DR   IARC_TP53; 28412
DR   Wikidata; Q54900282
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=1465024;
RX   PubMed=8180386;
RX   PubMed=9529133;
RX   PubMed=9738977;
RX   PubMed=10360377;
RX   PubMed=10995006;
RX   PubMed=14671638;
RX   PubMed=20519628;
RX   PubMed=20575032;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Sequence variation: Mutation; HGNC; HGNC:7978; NR3C1; Simple; p.Asn209Alafs*4 (c.624_625insGCCTGCG); Zygosity=Homozygous (PubMed=35124168).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Unspecified (PubMed=20575032).
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80342; B acute lymphoblastic leukemia with t(v;11q23.3) MLL rearranged
DI   ORDO; Orphanet_585918; B-lymphoblastic leukemia/lymphoma with t(v;11q23.3)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   9M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 23
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=1465024; DOI=10.1016/0145-2126(92)90113-L;
RA   Iida S., Saito M., Okazaki T., Seto M., Yamamoto K., Akao Y.,
RA   Ogura M., Suzuki H., Ariyoshi Y., Koike K., Nitta M., Takahashi T.,
RA   Ueda R., Nakazawa S.;
RT   "Phenotypic and genotypic characterization of 14 leukemia and lymphoma
RT   cell lines with 11q23 translocations.";
RL   Leuk. Res. 16:1155-1163(1992).
//
RX   PubMed=8180386; DOI=10.1182/blood.V83.10.2912.2912;
RA   Yamamoto K., Seto M., Iida S., Komatsu H., Kamada N., Kojima S.,
RA   Kodera Y., Nakazawa S., Saito H., Takahashi T., Ueda R.;
RT   "A reverse transcriptase-polymerase chain reaction detects
RT   heterogeneous chimeric mRNAs in leukemias with 11q23 abnormalities.";
RL   Blood 83:2912-2921(1994).
//
RX   PubMed=9529133; DOI=10.1038/sj.leu.2400951;
RA   Inukai T., Sugita K., Iijima K., Goi K., Tezuka T., Kojika S.,
RA   Kagami K., Mori T., Kinoshita A., Suzuki T., Koyama-Okazaki T.,
RA   Nakazawa S.;
RT   "Leukemic cells with 11q23 translocations express granulocyte
RT   colony-stimulating factor (G-CSF) receptor and their proliferation is
RT   stimulated with G-CSF.";
RL   Leukemia 12:382-389(1998).
//
RX   PubMed=9738977; DOI=10.1111/j.1349-7006.1998.tb03275.x; PMCID=PMC5921886;
RA   Takizawa J., Suzuki R., Kuroda H., Utsunomiya A., Kagami Y., Joh T.,
RA   Aizawa Y., Ueda R., Seto M.;
RT   "Expression of the TCL1 gene at 14q32 in B-cell malignancies but not
RT   in adult T-cell leukemia.";
RL   Jpn. J. Cancer Res. 89:712-718(1998).
//
RX   PubMed=10360377; DOI=10.1038/sj.leu.2401437;
RA   Nakamura M., Sugita K., Inukai T., Goi K., Iijima K., Tezuka T.,
RA   Kojika S., Shiraishi K., Miyamoto N., Karakida N., Kagami K.,
RA   Koyama-Okazaki T., Mori T., Nakazawa S.;
RT   "p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in
RT   childhood acute lymphoblastic leukemia with 11q23 translocation.";
RL   Leukemia 13:884-890(1999).
//
RX   PubMed=10995006; DOI=10.1038/sj.leu.2401893;
RA   Iijima K., Sugita K., Inukai T., Goi K., Tezuka T., Uno K., Sato H.,
RA   Kagami K., Nakazawa S.;
RT   "Expression of thrombopoietin receptor and its functional role in
RT   human B-precursor leukemia cells with 11q23 translocation or
RT   Philadelphia chromosome.";
RL   Leukemia 14:1598-1605(2000).
//
RX   PubMed=14671638; DOI=10.1038/sj.leu.2403236;
RA   Drexler H.G., Quentmeier H., MacLeod R.A.F.;
RT   "Malignant hematopoietic cell lines: in vitro models for the study of
RT   MLL gene alterations.";
RL   Leukemia 18:227-232(2004).
//
RX   PubMed=20519628; DOI=10.1182/blood-2009-09-244673;
RA   Hirose K., Inukai T., Kikuchi J., Furukawa Y., Ikawa T., Kawamoto H.,
RA   Oram S.H., Gottgens B., Kiyokawa N., Miyagawa Y., Okita H.,
RA   Akahane K., Zhang X.-C., Kuroda I., Honna H., Kagami K., Goi K.,
RA   Kurosawa H., Look A.T., Matsui H., Inaba T., Sugita K.;
RT   "Aberrant induction of LMO2 by the E2A-HLF chimeric transcription
RT   factor and its implication in leukemogenesis of B-precursor ALL with
RT   t(17;19).";
RL   Blood 116:962-970(2010).
//
RX   PubMed=20575032; DOI=10.1002/ajh.21738; PMCID=PMC7159455;
RA   Inukai T., Zhang X.-R., Kameyama T., Suzuki Y., Yoshikawa K., Kuroda I.,
RA   Nemoto A., Akahane K., Sato H., Goi K., Nakamoto K., Hamada J.-i.,
RA   Tada M., Moriuchi T., Sugita K.;
RT   "A specific linkage between the incidence of TP53 mutations and type
RT   of chromosomal translocations in B-precursor acute lymphoblastic
RT   leukemia cell lines.";
RL   Am. J. Hematol. 85:535-537(2010).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//