ID   WM9
AC   CVCL_6806
SY   WM-9; WM 9; WC00056
DR   BTO; BTO:0003438
DR   cancercelllines; CVCL_6806
DR   Coriell; WC00056
DR   Cosmic; 686408
DR   GEO; GSM186499
DR   GEO; GSM186500
DR   GEO; GSM952590
DR   IARC_TP53; 24990
DR   Progenetix; CVCL_6806
DR   Rockland; WM9-01-0001
DR   Wikidata; Q54994339
RX   PubMed=286328;
RX   PubMed=2068080;
RX   PubMed=3020539;
RX   PubMed=4053039;
RX   PubMed=8342600;
WW   https://www.wistar.org/our-scientists/meenhard-herlyn
CC   Part of: Wistar Institute melanoma cell line collection.
CC   Sequence variation: Gene deletion; HGNC; 9588; PTEN; Zygosity=Hemizygous (Wistar).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (Wistar).
CC   Omics: Transcriptome analysis by microarray.
CC   Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: D8S1179: 12,13->12,13,14.
CC   Discontinued: Coriell; WC00056; probable.
CC   Derived from site: Metastatic; Left axillary lymph node; UBERON=UBERON_0001097.
ST   Source(s): Wistar
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 9
ST   D16S539: 11,14
ST   D18S51: 13
ST   D19S433: 12,15
ST   D21S11: 29
ST   D2S1338: 24,25
ST   D3S1358: 14,17
ST   D5S818: 9,11
ST   D7S820: 9,11
ST   D8S1179: 12,13,14
ST   FGA: 20,25
ST   TH01: 7,9
ST   TPOX: 8,11
ST   vWA: 17,19
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 23
//
RX   PubMed=286328; DOI=10.1073/pnas.76.3.1438;
RA   Herlyn M., Steplewski Z., Herlyn D., Koprowski H.;
RT   "Colorectal carcinoma-specific antigen: detection by means of
RT   monoclonal antibodies.";
RL   Proc. Natl. Acad. Sci. U.S.A. 76:1438-1442(1979).
//
RX   PubMed=2068080; DOI=10.1073/pnas.88.14.6028;
RA   Cornil I., Theodorescu D., Man S., Herlyn M., Jambrosic J.A.,
RA   Kerbel R.S.;
RT   "Fibroblast cell interactions with human melanoma cells affect tumor
RT   cell growth as a function of tumor progression.";
RL   Proc. Natl. Acad. Sci. U.S.A. 88:6028-6032(1991).
//
RX   PubMed=3020539; DOI=10.1073/pnas.83.19.7197;
RA   Westermark B., Johnsson A., Paulsson Y., Betsholtz C., Heldin C.-H.,
RA   Herlyn M., Rodeck U., Koprowski H.;
RT   "Human melanoma cell lines of primary and metastatic origin express
RT   the genes encoding the chains of platelet-derived growth factor (PDGF)
RT   and produce a PDGF-like growth factor.";
RL   Proc. Natl. Acad. Sci. U.S.A. 83:7197-7200(1986).
//
RX   PubMed=4053039;
RA   Herlyn M., Thurin J., Balaban G.B., Bennicelli J.L., Herlyn D.,
RA   Elder D.E., Bondi E., Guerry D. IV, Nowell P.C., Clark W.H. Jr.,
RA   Koprowski H.;
RT   "Characteristics of cultured human melanocytes isolated from different
RT   stages of tumor progression.";
RL   Cancer Res. 45:5670-5676(1985).
//
RX   PubMed=8342600;
RA   Juhasz I., Albelda S.M., Elder D.E., Murphy G.F., Adachi K.,
RA   Herlyn D., Valyi-Nagy I.T., Herlyn M.;
RT   "Growth and invasion of human melanomas in human skin grafted to
RT   immunodeficient mice.";
RL   Am. J. Pathol. 143:528-537(1993).
//