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Cellosaurus WM46 (CVCL_6803)

[Text version]
Cell line name WM46
Synonyms WM-46; WM 46; WC00069
Accession CVCL_6803
Resource Identification Initiative To cite this cell line use: WM46 (RRID:CVCL_6803)
Comments Part of: Wistar Institute melanoma cell line collection.
Characteristics: Highly pigmented.
Omics: Transcriptome analysis by microarray.
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: D13S317: 11,13->14, D8S1179: 13,14->14 and FGA: 22,23,28->23.
Derived from site: Metastatic; Abdomen, skin; UBERON=UBERON_0001416.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (Wistar).
  • Gene deletion; HGNC; HGNC:1788; CDKN2B; Zygosity=Homozygous (Wistar).
  • Gene deletion; HGNC; HGNC:9588; PTEN; Zygosity=Hemizygous (Wistar).
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=18632627; Wistar).
  • Mutation; HGNC; HGNC:1773; CDK4; Simple; p.Arg24Cys (c.70C>T); ClinVar=VCV000016928; Zygosity=Unspecified (Wistar).
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 43Y
Category Cancer cell line
STR profile Source(s): Wistar

Markers:
AmelogeninX
CSF1PO11
D2S133817,18
D3S135815,17
D5S81812
D7S82011
D8S117914
D13S31714
D16S53911,14
D18S5119,20
D19S43313,14
D21S1129,30
FGA23
TH016
TPOX11
vWA17,19

Run an STR similarity search on this cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn
Publications

PubMed=4053039
Herlyn M., Thurin J., Balaban-Malenbaum G.B., Bennicelli J.L., Herlyn D., Elder D.E., Bondi E., Guerry D. 4th, Nowell P.C., Clark W.H. Jr., Koprowski H.
Characteristics of cultured human melanocytes isolated from different stages of tumor progression.
Cancer Res. 45:5670-5676(1985)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235; PMCID=PMC2615688
Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M.W., Herlyn M., Nathanson K.L.
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=18790768; DOI=10.1158/1535-7163.MCT-08-0431; PMCID=PMC2651569
Smalley K.S.M., Lioni M., Dalla Palma M., Xiao M., Desai B., Egyhazi Brage S., Hansson J., Wu H., King A.J., Van Belle P., Elder D.E., Flaherty K.T., Herlyn M., Nathanson K.L.
Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E-mutated melanomas.
Mol. Cancer Ther. 7:2876-2883(2008)

Cross-references
Cell line collections (Providers) Coriell; WC00069 - Discontinued
Rockland; WM46-01-0001
Cell line databases/resources cancercelllines; CVCL_6803
Encyclopedic resources Wikidata; Q54994306
Gene expression databases GEO; GSM186489
GEO; GSM186490
Polymorphism and mutation databases Cosmic; 1155269
Cosmic; 1155552
Cosmic; 1187582
Cosmic; 1303076
IARC_TP53; 24991
Progenetix; CVCL_6803
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number27