Cellosaurus logo
expasy logo

Cellosaurus WM1366 (CVCL_6789)

[Text version]
Cell line name WM1366
Synonyms WM-1366; WM 1366; WC00078; EST70
Accession CVCL_6789
Resource Identification Initiative To cite this cell line use: WM1366 (RRID:CVCL_6789)
Comments Part of: MD Anderson Cell Lines Project.
Part of: Wistar Institute melanoma cell line collection.
Omics: Array-based CGH.
Omics: Protein expression by reverse-phase protein arrays.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Caution: The reported STR profile from Wistar of this cell line was changed at one point between February 2016 when we retrieved them and entered them in the Cellosaurus and May 2018. The major changes were: CSF1PO: 11,12->12, D5S818: 12,13->13 and D7S820: 11,12->12.
Misspelling: Wn1366; Cosmic=1665010.
Derived from site: In situ; Forearm, skin; UBERON=UBERON_0003399.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; None_reported; -; Zygosity=- (Wistar).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Pro48Leu (c.143C>T); Zygosity=Unspecified (PubMed=17260012).
  • Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Leu (c.182A>T); ClinVar=VCV000375874; Zygosity=Heterozygous (PubMed=17260012; PubMed=23851445; PubMed=25645078; PubMed=25728708; Wistar).
  • Mutation; HGNC; 11998; TP53; Simple; p.Glu285Lys (c.853G>A); ClinVar=VCV000420133; Zygosity=Unspecified (PubMed=17260012; PubMed=23851445).
HLA typing Source: PubMed=15592718
Class I
HLA-AA*32:01,32:01
HLA-BB*41:01,41:01
HLA-CC*17:01,17:01
Class II
HLA-DPDPB1*03:01,03:01
HLA-DQDQB1*02:01,02:01
HLA-DRDRB1*03:01:02,03:01:02
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 79Y
Category Cancer cell line
STR profile Source(s): ESTDAB; Wistar

Markers:
AmelogeninX
CSF1PO12
D2S133820,22
D3S135815,18
D5S81813
D7S82012
D8S117913,14
D13S3178,13
D16S53912,13
D18S5112,16
D19S43314,15
D21S1128,30
FGA21,22
TH016,7
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Web pages https://www.wistar.org/our-scientists/meenhard-herlyn
https://tcpaportal.org/mclp/
Publications

PubMed=15592718; DOI=10.1007/s00262-004-0561-5
Rodriguez T., Mendez R., Roberts C.H., Ruiz-Cabello F., Dodi I.A., Lopez Nevot M.A., Paco L., Maleno I., Marsh S.G.E., Pawelec G., Garrido F.
High frequency of homozygosity of the HLA region in melanoma cell lines reveals a pattern compatible with extensive loss of heterozygosity.
Cancer Immunol. Immunother. 54:141-148(2005)

PubMed=16827748; DOI=10.1111/j.1600-0749.2006.00322.x
Hoek K.S., Schlegel N.C., Brafford P., Sucker A., Ugurel S., Kumar R., Weber B.L., Nathanson K.L., Phillips D.J., Herlyn M., Schadendorf D., Dummer R.
Metastatic potential of melanomas defined by specific gene expression profiles with no BRAF signature.
Pigment Cell Res. 19:290-302(2006)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=18632627; DOI=10.1158/0008-5472.CAN-08-0235
Smalley K.S.M., Contractor R., Nguyen T.K., Xiao M., Edwards R., Muthusamy V., King A.J., Flaherty K.T., Bosenberg M.W., Herlyn M., Nathanson K.L.
Identification of a novel subgroup of melanomas with KIT/cyclin-dependent kinase-4 overexpression.
Cancer Res. 68:5743-5752(2008)

PubMed=19340423; DOI=10.1007/s00262-009-0701-z
Mendez R., Aptsiauri N., Del Campo A., Maleno I., Cabrera T., Ruiz-Cabello F., Garrido F., Garcia-Lora A.
HLA and melanoma: multiple alterations in HLA class I and II expression in human melanoma cell lines from ESTDAB cell bank.
Cancer Immunol. Immunother. 58:1507-1515(2009)

PubMed=23851445; DOI=10.1158/1541-7786.MCR-13-0006
Dahl C., Christensen C., Jonsson G., Lorentzen A., Skjodt M.L., Borg A., Pawelec G., Guldberg P.
Mutual exclusivity analysis of genetic and epigenetic drivers in melanoma identifies a link between p14 ARF and RARbeta signaling.
Mol. Cancer Res. 11:1166-1178(2013)

PubMed=25502142; DOI=10.1038/ncomms6712
Muller J., Krijgsman O., Tsoi J., Robert L., Hugo W., Song C., Kong X.-J., Possik P.A., Cornelissen-Steijger P.D.M., Geukes Foppen M.H., Kemper K., Goding C.R., McDermott U., Blank C., Haanen J.B.A.G., Graeber T.G., Ribas A., Lo R.S., Peeper D.S.
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma.
Nat. Commun. 5:5712.1-5712.15(2014)

PubMed=25645078; DOI=10.1186/s12943-015-0293-5
Atefi M., Titz B., Avramis E., Ng C., Wong D.J.L., Lassen A., Cerniglia M., Escuin-Ordinas H., Foulad D., Comin-Anduix B., Graeber T.G., Ribas A.
Combination of pan-RAF and MEK inhibitors in NRAS mutant melanoma.
Mol. Cancer 14:27.1-27.12(2015)

PubMed=25728708; DOI=10.1111/pcmr.12364
Vogel C.J., Smit M.A., Maddalo G., Possik P.A., Sparidans R.W., van der Burg S.H., Verdegaal E.M.E., Heck A.J.R., Samatar A.A., Beijnen J.H., Altelaar A.F.M., Peeper D.S.
Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK.
Pigment Cell Melanoma Res. 28:307-317(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

Cross-references
Cell line collections (Providers) Coriell; WC00078 - Discontinued
Rockland; WM1366-01-0001
Cell line databases/resources cancercelllines; CVCL_6789
ESTDAB; ESTDAB-070
SKY/M-FISH/CGH; 4947
Encyclopedic resources Wikidata; Q54994172
Gene expression databases GEO; GSM109027
GEO; GSM185178
GEO; GSM185179
GEO; GSM185180
GEO; GSM185181
GEO; GSM188064
GEO; GSM188116
GEO; GSM188189
GEO; GSM188204
GEO; GSM188217
GEO; GSM188231
GEO; GSM188261
GEO; GSM188280
GEO; GSM188289
GEO; GSM188320
GEO; GSM952594
GEO; GSM1507941
Polymorphism and mutation databases Cosmic; 1047650
Cosmic; 1155539
Cosmic; 1665010
Cosmic; 2163800
IARC_TP53; 26077
Progenetix; CVCL_6789
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number32