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Cellosaurus TM-31 (CVCL_6735)

[Text version]
Cell line name TM-31
Synonyms TM31
Accession CVCL_6735
Resource Identification Initiative To cite this cell line use: TM-31 (RRID:CVCL_6735)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: TCGA-110-CL cell line panel.
Population: Japanese.
Doubling time: 65 hours (Note=At 50th passage), 62 hours (Note=At 220th passage) (PubMed=11213969).
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Brain; UBERON=UBERON_0000955.
Sequence variations
  • Mutation; HGNC; 11998; TP53; Simple; p.Cys238Gly (c.712T>G); ClinVar=VCV000376577; Zygosity=Homozygous (PubMed=11213969; DepMap).
HLA typing Source: PubMed=26589293
Class I
HLA-AA*24:02,24:02
HLA-BB*07:02,51:01
HLA-CC*07:02,14:02
Genome ancestry Source: PubMed=30894373

Origin% genome
African1.8
Native American0
East Asian, North80.56
East Asian, South14.37
South Asian0
European, North0
European, South3.26
Disease Astrocytoma (NCIt: C60781)
Neurofibromatosis type 1 (NCIt: C3273)
Astrocytoma (ORDO: Orphanet_94)
Neurofibromatosis type 1 (ORDO: Orphanet_636)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 42Y
Category Cancer cell line
STR profile Source(s): RCB

Markers:
AmelogeninX
CSF1PO11,12
D5S81810
D7S82011,12
D13S31711,14
D16S5399,12
TH019
TPOX8,11
vWA19

Run an STR similarity search on this cell line
Publications

PubMed=11213969; DOI=10.3171/jns.2001.94.2.0301
Kurimoto M., Hirashima Y., Ogiichi T., Hamada H., Kamiyama H., Endo S.
Establishment and characterization of a novel malignant astrocytoma cell line derived from a tumor removed in a patient with neurofibromatosis type 1.
J. Neurosurg. 94:301-308(2001)

PubMed=11213978
Couldwell W.T.
Astrocytoma cell line.
J. Neurosurg. 94:348-349(2001)

PubMed=22460905; DOI=10.1038/nature11003
Barretina J.G., Caponigro G., Stransky N., Venkatesan K., Margolin A.A., Kim S., Wilson C.J., Lehar J., Kryukov G.V., Sonkin D., Reddy A., Liu M., Murray L., Berger M.F., Monahan J.E., Morais P., Meltzer J., Korejwa A., Jane-Valbuena J., Mapa F.A., Thibault J., Bric-Furlong E., Raman P., Shipway A., Engels I.H., Cheng J., Yu G.-Y.K., Yu J.-J., Aspesi P. Jr., de Silva M., Jagtap K., Jones M.D., Wang L., Hatton C., Palescandolo E., Gupta S., Mahan S., Sougnez C., Onofrio R.C., Liefeld T., MacConaill L.E., Winckler W., Reich M., Li N.-X., Mesirov J.P., Gabriel S.B., Getz G., Ardlie K., Chan V., Myer V.E., Weber B.L., Porter J., Warmuth M., Finan P., Harris J.L., Meyerson M.L., Golub T.R., Morrissey M.P., Sellers W.R., Schlegel R., Garraway L.A.
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
Nature 483:603-607(2012)

PubMed=26589293; DOI=10.1186/s13073-015-0240-5
Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P., Loewer M., Sahin U., Castle J.C.
TCLP: an online cancer cell line catalogue integrating HLA type, predicted neo-epitopes, virus and gene expression.
Genome Med. 7:118.1-118.7(2015)

PubMed=30894373; DOI=10.1158/0008-5472.CAN-18-2747
Dutil J., Chen Z.-H., Monteiro A.N.A., Teer J.K., Eschrich S.A.
An interactive resource to probe genetic diversity and estimated ancestry in cancer cell lines.
Cancer Res. 79:1263-1273(2019)

PubMed=31068700; DOI=10.1038/s41586-019-1186-3
Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C., McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X., Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F., Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R., Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C., Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A., Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D., Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L., Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A., Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D., Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M., Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R., Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A., Sellers W.R.
Next-generation characterization of the Cancer Cell Line Encyclopedia.
Nature 569:503-508(2019)

PubMed=31395879; DOI=10.1038/s41467-019-11415-2
Yu K., Chen B., Aran D., Charalel J., Yau C., Wolf D.M., van 't Veer L.J., Butte A.J., Goldstein T., Sirota M.
Comprehensive transcriptomic analysis of cell lines as models of primary tumors across 22 tumor types.
Nat. Commun. 10:3574.1-3574.11(2019)

Cross-references
Cell line collections (Providers) BCRJ; 0379
RCB; RCB1731
Cell line databases/resources CLO; CLO_0050635
cancercelllines; CVCL_6735
Cell_Model_Passport; SIDM01460
DepMap; ACH-000592
Biological sample resources BioSample; SAMN03472072
BioSample; SAMN10987718
Chemistry resources PharmacoDB; TM31_1598_2019
Encyclopedic resources Wikidata; Q54972649
Gene expression databases ArrayExpress; E-MTAB-2770
GEO; GSM887707
GEO; GSM888800
Polymorphism and mutation databases IARC_TP53; 14834
LiGeA; CCLE_306
Progenetix; CVCL_6735
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number25