Cell line name |
MCF-7N |
Synonyms |
MCF-7 N; MCF-7n |
Accession |
CVCL_6673 |
Resource Identification Initiative |
To cite this cell line use: MCF-7N (RRID:CVCL_6673) |
Comments |
Population: Caucasian. Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175. |
Sequence variations |
- Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
- Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Invasive breast carcinoma of no special type (NCIt: C4194) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0031 (MCF-7) Children:
|
Sex of cell |
Female |
Age at sampling |
69Y |
Category |
Cancer cell line |
Publications | PubMed=10811993; DOI=10.3892/ijo.16.6.1179 Burow M.E., Weldon C.B., Chiang T.-C., Tang Y., Collins-Burow B.M., Rolfe K., Li S.-F., McLachlan J.A., Beckman B.S. Differences in protein kinase C and estrogen receptor alpha, beta expression and signaling correlate with apoptotic sensitivity of MCF-7 breast cancer cell variants. Int. J. Oncol. 16:1179-1187(2000) PubMed=15138590; DOI=10.3892/ijo.24.6.1473 Weldon C.B., Parker A.P., Patten D., Elliott S., Tang Y., Frigo D.E., Dugan C.M., Coakley E.L., Butler N.N., Clayton J.L., Alam J., Curiel T.J., Beckman B.S., Jaffe B.M., Burow M.E. Sensitization of apoptotically-resistant breast carcinoma cells to TNF and TRAIL by inhibition of p38 mitogen-activated protein kinase signaling. Int. J. Oncol. 24:1473-1480(2004) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_6673
|
Encyclopedic resources |
Wikidata; Q54904408
|
Entry history |
Entry creation | 04-Apr-2012 |
Last entry update | 05-Oct-2023 |
Version number | 20 |
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