ID   HTOG
AC   CVCL_6656
DR   Wikidata; Q54896671
RX   PubMed=2429643;
RX   PubMed=2448191;
RX   PubMed=6323807;
RX   PubMed=9436037;
RX   PubMed=10457904;
RX   PubMed=15541573;
CC   Population: Japanese.
CC   Characteristics: Established from the granulosa cells of a granulosa-theca cell tumor.
CC   Doubling time: 46.2 hours (Note=At 5th passage), 28.4 hours (Note=At 20th passage), 23.8 hours (Note=At 40th passage) (PubMed=6323807); 25 hours (PubMed=10457904).
CC   Derived from site: In situ; Ovary, ovarian follicle, granulosa cell layer; UBERON=UBERON_0005170.
CC   Cell type: Granulosa cell; CL=CL_0000501.
DI   NCIt; C6261; Ovarian granulosa cell tumor
DI   ORDO; Orphanet_99915; Maligant granulosa cell tumor of the ovary
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_6657 ! HTOT
SX   Female
AG   74Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 17
//
RX   PubMed=2429643; DOI=10.1111/j.1447-0756.1986.tb00192.x;
RA   Ishiwata I., Ishiwata C., Nozawa S., Ishikawa H.;
RT   "CA125 production by gynecologic tumors in vitro and its modulation
RT   induced by dibutyl cyclic adenosine monophosphate.";
RL   Asia Oceania J. Obstet. Gynaecol. 12:285-290(1986).
//
RX   PubMed=2448191; DOI=10.1016/0090-8258(88)90151-5;
RA   Ishiwata I., Ishiwata C., Soma M., Ono I., Nakaguchi T., Ishikawa H.;
RT   "Tumor angiogenic activity of gynecologic tumor cell lines on the
RT   chorioallantoic membrane.";
RL   Gynecol. Oncol. 29:87-93(1988).
//
RX   PubMed=6323807; DOI=10.1093/jnci/72.4.789;
RA   Ishiwata I., Ishiwata C., Soma M., Kobayashi N., Ishikawa H.;
RT   "Establishment and characterization of an estrogen-producing human
RT   ovarian granulosa tumor cell line.";
RL   J. Natl. Cancer Inst. 72:789-800(1984).
//
RX   PubMed=9436037;
RA   Soma M., Ishiwata I., Ishiwata C., Nakaguchi T., Ono I., Kiguchi K.,
RA   Hashimoto H., Tachibana T., Ishikawa H., Nozawa S.;
RT   "Tissue reconstruction of gynecologic tumor cells in the rotation
RT   culture system.";
RL   Hum. Cell 10:175-181(1997).
//
RX   PubMed=10457904;
RA   Ishiwata I., Sudo T., Kiguchi K., Ishikawa H.;
RT   "Tumor angiogenesis factors produced by cancer cells.";
RL   Hum. Cell 12:37-46(1999).
//
RX   PubMed=15541573; DOI=10.1016/j.mce.2004.04.018;
RA   Havelock J.C., Rainey W.E., Carr B.R.;
RT   "Ovarian granulosa cell lines.";
RL   Mol. Cell. Endocrinol. 228:67-78(2004).
//