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Cellosaurus DM13 (CVCL_6621)

[Text version]
Cell line name DM13
Synonyms DM-13; Duke Melanoma 13
Accession CVCL_6621
Resource Identification Initiative To cite this cell line use: DM13 (RRID:CVCL_6621)
Comments From: Duke University Medical Center; Durham; USA.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
Sequence variations
HLA typing Source: PubMed=2404572
Class I
HLA-AA*02,31
HLA-BB*13,18
Disease Melanoma (NCIt: C3224)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_ZL67 (DM13/B7-7)
Category Cancer cell line
Publications

PubMed=2785141; DOI=10.4049/jimmunol.142.9.3329
Darrow T.L., Slingluff C.L. Jr., Seigler H.F.
The role of HLA class I antigens in recognition of melanoma cells by tumor-specific cytotoxic T lymphocytes. Evidence for shared tumor antigens.
J. Immunol. 142:3329-3335(1989)

PubMed=2404572
Crowley N.J., Slingluff C.L. Jr., Darrow T.L., Seigler H.F.
Generation of human autologous melanoma-specific cytotoxic T-cells using HLA-A2-matched allogeneic melanomas.
Cancer Res. 50:492-498(1990)

PubMed=7703289; DOI=10.1089/hum.1995.6.1-87
Fenton R.T., Sznol M., Luster D.G., Taub D.D., Longo D.L.
A phase I trial of B7-transfected or parental lethally irradiated allogeneic melanoma cell lines to induce cell-mediated immunity against tumor-associated antigen presented by HLA-A2 or HLA-A1 in patients with stage IV melanoma. NCI protocol T93-0161. BRMP protocol 9401.
Hum. Gene Ther. 6:87-106(1995)

PubMed=10752474; DOI=10.1007/s002620050015; PMCID=PMC11037162
Slingluff C.L. Jr., Colella T.A., Thompson L., Graham D.D., Skipper J.C.A., Caldwell J., Brinckerhoff L., Kittlesen D.J., Deacon D.H., Oei C., Harthun N.L., Huczko E.L., Hunt D.F., Darrow T.L., Engelhard V.H.
Melanomas with concordant loss of multiple melanocytic differentiation proteins: immune escape that may be overcome by targeting unique or undefined antigens.
Cancer Immunol. Immunother. 48:661-672(2000)

PubMed=14871852; DOI=10.1158/0008-5472.CAN-03-2209
Hogan K.T., Coppola M.A., Gatlin C.L., Thompson L.W., Shabanowitz J., Hunt D.F., Engelhard V.H., Ross M.M., Slingluff C.L. Jr.
Identification of novel and widely expressed cancer/testis gene isoforms that elicit spontaneous cytotoxic T-lymphocyte reactivity to melanoma.
Cancer Res. 64:1157-1163(2004)

PubMed=21654344; DOI=10.1097/CMR.0b013e328343a1d6; PMCID=PMC3131461
Molhoek K.R., Shada A.L., Smolkin M., Chowbina S., Papin J., Brautigan D.L., Slingluff C.L. Jr.
Comprehensive analysis of receptor tyrosine kinase activation in human melanomas reveals autocrine signaling through IGF-1R.
Melanoma Res. 21:274-284(2011)

PubMed=26405815; DOI=10.1371/journal.pone.0138210; PMCID=PMC4583389
Capaldo B.J., Roller D.G., Axelrod M.J., Koeppel A.F., Petricoin E.F. 3rd, Slingluff C.L. Jr., Weber M.J., Mackey A.J., Gioeli D., Bekiranov S.
Systems analysis of adaptive responses to MAP kinase pathway blockade in BRAF mutant melanoma.
PLoS ONE 10:E0138210-E0138210(2015)

PubMed=26673621; DOI=10.18632/oncotarget.6548; PMCID=PMC4823068
Roller D.G., Capaldo B.J., Bekiranov S., Mackey A.J., Conaway M.R., Petricoin E.F. 3rd, Gioeli D., Weber M.J.
Combinatorial drug screening and molecular profiling reveal diverse mechanisms of intrinsic and adaptive resistance to BRAF inhibition in V600E BRAF mutant melanomas.
Oncotarget 7:2734-2753(2016)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6621
Encyclopedic resources Wikidata; Q54831199
Gene expression databases GEO; GSM1572817
GEO; GSM1572818
GEO; GSM1572819
GEO; GSM1572820
GEO; GSM1572821
GEO; GSM1572822
GEO; GSM1671960
GEO; GSM1671989
GEO; GSM1672012
GEO; GSM1672071
GEO; GSM1672076
GEO; GSM1672098
GEO; GSM1672101
GEO; GSM1672115
GEO; GSM1672131
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number19