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Cellosaurus CHLA-10 (CVCL_6583)

[Text version]
Cell line name CHLA-10
Synonyms CHLA10
Accession CVCL_6583
Resource Identification Initiative To cite this cell line use: CHLA-10 (RRID:CVCL_6583)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Part of: MD Anderson Cell Lines Project.
Part of: NCI Pediatric Preclinical Testing Program (PPTP) cell line panel.
Doubling time: 24 hours (PubMed=20922763); 32 hours (PubMed=24312454).
Omics: Deep exome analysis.
Omics: Protein expression by reverse-phase protein arrays.
Omics: scRNAseq analysis.
Derived from site: Metastatic; Thoracic lymph duct; UBERON=UBERON_0007644.
Disease Primitive neuroectodermal tumor (NCIt: C3716)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_M150 ! CHLA-9
Sex of cell Female
Age at sampling 14Y
Category Cancer cell line
STR profile Source(s): COG; PubMed=20922763; PubMed=24312454

Markers:
AmelogeninX
CSF1PO12
D2S133820
D3S135815
D5S81812
D7S8209,10
D8S117910,13
D13S31712
D16S53911
D18S5112,14
D19S43312,13
D21S1128,29
FGA23
TH017
TPOX11
vWA16

Run an STR similarity search on this cell line
Web pages https://www.cccells.org/PDF_Files/Brain/CHLA-10%20Cell%20Line%20Data%20Sheet.pdf
https://www.cccells.org/tables/Ewings.php
http://www.pptpinvitro.org/cell_lines_panel.php
https://tcpaportal.org/mclp/
Publications

PubMed=11212268
Thompson P.M., Maris J.M., Hogarty M.D., Seeger R.C., Reynolds C.P., Brodeur G.M., White P.S.
Homozygous deletion of CDKN2A (p16INK4a/p14ARF) but not within 1p36 or at other tumor suppressor loci in neuroblastoma.
Cancer Res. 61:679-686(2001)

PubMed=15289350; DOI=10.1158/0008-5472.CAN-04-0377
Batra S., Reynolds C.P., Maurer B.J.
Fenretinide cytotoxicity for Ewing's sarcoma and primitive neuroectodermal tumor cell lines is decreased by hypoxia and synergistically enhanced by ceramide modulators.
Cancer Res. 64:5415-5424(2004)

PubMed=20922763; DOI=10.1002/pbc.22801
Kang M.H., Smith M.A., Morton C.L., Keshelava N., Houghton P.J., Reynolds C.P.
National Cancer Institute pediatric preclinical testing program: model description for in vitro cytotoxicity testing.
Pediatr. Blood Cancer 56:239-249(2011)

PubMed=24312454; DOI=10.1371/journal.pone.0080060
May W.A., Grigoryan R.S., Keshelava N., Cabral D.J., Christensen L.L., Jenabi J., Ji L.-Y., Triche T.J., Lawlor E.R., Reynolds C.P.
Characterization and drug resistance patterns of Ewing's sarcoma family tumor cell lines.
PLoS ONE 8:E80060-E80060(2013)

PubMed=26351324; DOI=10.1158/1535-7163.MCT-15-0074
Teicher B.A., Polley E.C., Kunkel M., Evans D., Silvers T.E., Delosh R.M., Laudeman J., Ogle C., Reinhart R., Selby M., Connelly J., Harris E., Monks A., Morris J.
Sarcoma cell line screen of oncology drugs and investigational agents identifies patterns associated with gene and microRNA expression.
Mol. Cancer Ther. 14:2452-2462(2015)

PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005
Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P., Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L., Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D., Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B., Liang H.
Characterization of human cancer cell lines by reverse-phase protein arrays.
Cancer Cell 31:225-239(2017)

DOI=10.5282/edoc.27750
Orth M.F.
Systematic multi-omics profiling of Ewing sarcoma cell lines.
Thesis PhD (2021), Ludwig Maximilians University of Munich, Germany

Cross-references
Cell line databases/resources cancercelllines; CVCL_6583
Cell_Model_Passport; SIDM01542
DepMap; ACH-001029
Encyclopedic resources Wikidata; Q54812148
Gene expression databases GEO; GSM1676328
GEO; GSM1701625
GEO; GSM4368463
Polymorphism and mutation databases Cosmic; 930038
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number20