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Cellosaurus BEL-7404 (CVCL_6568)

[Text version]
Cell line name BEL-7404
Synonyms Bel-7404; BEL 7404; Bel 7404; BEL7404; Bel7404; 7404
Accession CVCL_6568
Resource Identification Initiative To cite this cell line use: BEL-7404 (RRID:CVCL_6568)
Comments Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=28807831). Originally thought to originate from a 69 year old male patient with a hepatocellular carcinoma.
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00550.
Population: African American.
Doubling time: 26 hours (PubMed=6154311).
Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Miscellaneous: Formerly the CCRID database had an entry describing this cell line (3131C0001000700064). It was the sole source for the STR profile of this entry.
Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
Disease Human papillomavirus-related cervical adenocarcinoma (NCIt: C27677)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0030 (HeLa)
Children:
CVCL_IP16 (BEL-7404-CP.3)
Sex of cell Female
Age at sampling 30Y6M
Category Cancer cell line
STR profile Source(s): CCRID

Markers:
AmelogeninX
CSF1PO9,10
D2S133817
D3S135818
D5S81811,12
D7S8208,12
D8S117912
D13S31712,13.3
D16S5399,10
D18S5116
D19S43313,14
D21S1127,28
FGA21
TH017
TPOX8,12
vWA16,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=6154311; DOI=10.1360/ya1980-23-2-236
Chen R.-M., Zhu D.-H., Ye X.-Z., Shen D.-W., Lu R.-H.
Establishment of three human liver carcinoma cell lines and some of their biological characteristics in vitro.
Sci. Sin. 23:236-247(1980)

PubMed=6275024; DOI=10.1099/0022-1317-57-1-95
Koshy R., Maupas P., Muller R., Hofschneider P.H.
Detection of hepatitis B virus-specific DNA in the genomes of human hepatocellular carcinoma and liver cirrhosis tissues.
J. Gen. Virol. 57:95-102(1981)

DOI=10.1007/978-4-431-68349-0_4
Alexander J.J.
Human hepatoma cell lines.
(In) Neoplasms of the liver; Okuda K., Ishak K.G. (eds.); pp.47-56; Springer; Tokyo (1987)

PubMed=11774261; DOI=10.1002/ijc.1597
Zhang R., Wang X., Guo L., Xie H.
Growth inhibition of BEL-7404 human hepatoma cells by expression of mutant telomerase reverse transcriptase.
Int. J. Cancer 97:173-179(2002)

PubMed=23505090; DOI=10.1002/hep.26402
Wang K., Lim H.Y., Shi S., Lee J., Deng S.-B., Xie T., Zhu Z., Wang Y.-L., Pocalyko D., Yang W.J., Rejto P.A., Mao M., Park C.-K., Xu J.-C.
Genomic landscape of copy number aberrations enables the identification of oncogenic drivers in hepatocellular carcinoma.
Hepatology 58:706-717(2013)

PubMed=28807831; DOI=10.1016/j.jhep.2017.08.002
Rebouissou S., Zucman-Rossi J., Moreau R., Qiu Z.-X., Hui L.-J.
Note of caution: contaminations of hepatocellular cell lines.
J. Hepatol. 67:896-897(2017)

Cross-references
Anatomy/cell type resources BTO; BTO:0005814
Chemistry resources ChEMBL-Cells; CHEMBL3307908
ChEMBL-Targets; CHEMBL614280
PubChem_Cell_line; CVCL_6568
Encyclopedic resources Wikidata; Q54795973
Gene expression databases GEO; GSM743502
GEO; GSM936755
GEO; GSM1374401
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number27