ID   WIL2
AC   CVCL_6544
SY   WIL-2; Wil.2; WI-L2; Wi-L2
DR   BTO; BTO:0001523
DR   ChEMBL-Cells; CHEMBL3308011
DR   ChEMBL-Targets; CHEMBL612809
DR   CLS; 302011
DR   PubChem_Cell_line; CVCL_6544
DR   Wikidata; Q54994064
RX   PubMed=174085;
RX   PubMed=197600;
RX   PubMed=893394;
RX   PubMed=1260760;
RX   PubMed=4102022;
RX   PubMed=4323138;
RX   PubMed=4527800;
RX   PubMed=5087481;
RX   PubMed=5673231;
RX   PubMed=6600440;
RX   PubMed=8316623;
CC   Population: Caucasian.
CC   HLA typing: A*01:01:01,02:01:01; B*53:38:02,57:01:01; C*06:02:01,14:02:01; DPB1*13:01:01G,16:01:01; DQA1*02:01:01; DQB1*02:02:01G,03:03:02; DRB1*07:01:01 (CLS=302011).
CC   Sequence variation: Mutation; HGNC; 11272; SPTA1; Simple; p.Ser1163Ala (c.3487T>G); ClinVar=VCV000258929; Zygosity=Homozygous (from child cell lines TK6; WIL2 NS).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Misspelling: W1-L2; Note=Occasionally.
CC   Misspelling: WI-L; Note=Occasionally.
CC   Derived from site: In situ; Spleen; UBERON=UBERON_0002106.
ST   Source(s): CLS=302011
ST   Amelogenin: X,Y
ST   CSF1PO: 11,12
ST   D13S317: 11
ST   D16S539: 11,12
ST   D18S51: 11,16
ST   D19S433: 14,16
ST   D21S11: 29
ST   D2S1338: 17,25
ST   D3S1358: 16
ST   D5S818: 12,13
ST   D7S820: 9,11
ST   D8S1179: 10,13
ST   FGA: 22,24
ST   TH01: 8,9.3
ST   TPOX: 8,11
ST   vWA: 17,20
DI   NCIt; C97074; Hereditary spherocytosis
DI   ORDO; Orphanet_822; Hereditary spherocytosis
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   5Y
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 26
//
RX   PubMed=174085; DOI=10.1073/pnas.72.12.4971;
RA   Stiles C.D., Desmond W. Jr., Sato G.H., Saier M.H. Jr.;
RT   "Failure of human cells transformed by simian virus 40 to form tumors
RT   in athymic nude mice.";
RL   Proc. Natl. Acad. Sci. U.S.A. 72:4971-4975(1975).
//
RX   PubMed=197600; DOI=10.1126/science.197600;
RA   Hershfield M.S., Snyder F.F., Seegmiller J.E.;
RT   "Adenine and adenosine are toxic to human lymphoblast mutants
RT   defective in purine salvage enzymes.";
RL   Science 197:1284-1287(1977).
//
RX   PubMed=893394; DOI=10.1016/S0021-9258(17)40020-2;
RA   Hershfield M.S., Seegmiller J.E.;
RT   "Regulation of de novo purine synthesis in human lymphoblasts. Similar
RT   rates of de novo synthesis during growth by normal cells and mutants
RT   deficient in hypoxanthine-guanine phosphoribosyltransferase
RT   activity.";
RL   J. Biol. Chem. 252:6002-6010(1977).
//
RX   PubMed=1260760;
RA   Stiles C.D., Desmond W. Jr., Chuman L.M., Sato G.H., Saier M.H. Jr.;
RT   "Growth control of heterologous tissue culture cells in the
RT   congenitally athymic nude mouse.";
RL   Cancer Res. 36:1353-1360(1976).
//
RX   PubMed=4102022; DOI=10.1002/jcp.1040770215;
RA   Lerner R.A., Hodge L.D.;
RT   "Gene expression in synchronized lymphocytes: studies on the control
RT   of synthesis of immunoglobulin polypeptides.";
RL   J. Cell. Physiol. 77:265-276(1971).
//
RX   PubMed=4323138; DOI=10.1093/jnci/46.3.647;
RA   Levy J.A., Buell D.N., Creech C., Hirshaut Y., Silverberg H.;
RT   "Further characterization of the WI-L1 and WI-L2 lymphoblastoid
RT   lines.";
RL   J. Natl. Cancer Inst. 46:647-654(1971).
//
RX   PubMed=4527800; DOI=10.1073/pnas.71.7.2679;
RA   Lever J.E., Nuki G., Seegmiller J.E.;
RT   "Expression of purine overproduction in a series of
RT   8-azaguanine-resistant diploid human lymphoblast lines.";
RL   Proc. Natl. Acad. Sci. U.S.A. 71:2679-2683(1974).
//
RX   PubMed=5087481; DOI=10.1126/science.173.3991.60;
RA   Lerner R.A., McConahey P.J., Dixon F.J.;
RT   "Quantitative aspects of plasma membrane-associated immunoglobulin in
RT   clones of diploid human lymphocytes.";
RL   Science 173:60-62(1971).
//
RX   PubMed=5673231; DOI=10.1002/1097-0142(196809)22:3<517::AID-CNCR2820220305>3.0.CO;2-A;
RA   Levy J.A., Virolainen M., Defendi V.;
RT   "Human lymphoblastoid lines from lymph node and spleen.";
RL   Cancer 22:517-524(1968).
//
RX   PubMed=6600440; DOI=10.1007/BF02617996;
RA   Uittenbogaart C.H., Cantor Y., Fahey J.L.;
RT   "Growth of human malignant lymphoid cell lines in serum-free medium.";
RL   In Vitro 19:67-72(1983).
//
RX   PubMed=8316623; DOI=10.2307/3578190;
RA   Evans H.H., Ricanati M., Horng M.-F., Jiang Q.-Y., Mencl J.,
RA   Olive P.L.;
RT   "DNA double-strand break rejoining deficiency in TK6 and other human
RT   B-lymphoblast cell lines.";
RL   Radiat. Res. 134:307-315(1993).
//