ID   KTC-2
AC   CVCL_6476
SY   KTC2
DR   cancercelllines; CVCL_6476
DR   Cosmic; 1239964
DR   Cosmic; 2054080
DR   Wikidata; Q54900621
RX   CelloPub=CLPUB00144;
RX   PubMed=12729473;
RX   PubMed=18713817;
RX   PubMed=23833040;
RX   PubMed=25675381;
RX   PubMed=30737244;
CC   Population: Japanese.
CC   Doubling time: 36 +- 3 hours (PubMed=12729473).
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Glu490Ter (c.1468G>T); Zygosity=Heterozygous (PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): PubMed=18713817; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 12,13
ST   D13S317: 8,12
ST   D16S539: 10,11
ST   D18S51: 16
ST   D21S11: 30
ST   D3S1358: 15
ST   D5S818: 12
ST   D7S820: 11
ST   D8S1179: 12
ST   FGA: 23
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C3878; Thyroid gland anaplastic carcinoma
DI   ORDO; Orphanet_142; Anaplastic thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   70Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 21
//
RX   CelloPub=CLPUB00144;
RA   Kurebayashi, Junichi
RA   Tanaka, Katsuhiro
RA   Yamamoto, Yutaka
RA   Okubo, Sumiko
RA   Sonoo, Hiroshi
RT   "Human epidermal growth factor receptor 1 and thrombospondin-1 in
RT   thyroid cancer.";
RL   (In book chapter) Trends in thyroid cancer research. Horizons in cancer research, Vol. 37; Milton, Carl A. (eds.); pp.89-116; Nova Science Publishers; Hauppauge; USA (2007).
//
RX   PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569;
RA   Schweppe, Rebecca E.
RA   Klopper, Joshua Paul
RA   Korch, Christopher T.
RA   Pugazhenthi, Umarani
RA   Benezra, Miriam
RA   Knauf, Jeffrey A.
RA   Fagin, James Alexander
RA   Marlow, Laura A.
RA   Copland, John Alton 3rd
RA   Smallridge, Robert Christian
RA   Haugen, Bryan R.
RT   "Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer
RT   cell lines reveals cross-contamination resulting in cell line
RT   redundancy and misidentification.";
RL   J. Clin. Endocrinol. Metab. 93:4331-4341(2008).
//
RX   PubMed=12729473; DOI=10.1089/105072503321582042;
RA   Kurebayashi, Junichi
RA   Otsuki, Takemi
RA   Tanaka, Katsuhiro
RA   Yamamoto, Yutaka
RA   Moriya, Takuya
RA   Sonoo, Hiroshi
RT   "Medroxyprogesterone acetate decreases secretion of interleukin-6 and
RT   parathyroid hormone-related protein in a new anaplastic thyroid cancer
RT   cell line, KTC-2.";
RL   Thyroid 13:249-258(2003).
//
RX   PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971;
RA   Landa, Inigo
RA   Ganly, Ian
RA   Chan, Timothy A.
RA   Mitsutake, Norisato
RA   Matsuse, Michiko
RA   Ibrahimpasic, Tihana
RA   Ghossein, Ronald A.
RA   Fagin, James Alexander
RT   "Frequent somatic TERT promoter mutations in thyroid cancer: higher
RT   prevalence in advanced forms of the disease.";
RL   J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa, Inigo
RA   Pozdeyev, Nikita
RA   Korch, Christopher T.
RA   Marlow, Laura A.
RA   Smallridge, Robert Christian
RA   Copland, John Alton 3rd
RA   Henderson, Ying C.
RA   Lai, Stephen Y.
RA   Clayman, Gary L.
RA   Onoda, Naoyoshi
RA   Tan, Aik-Choon
RA   Garcia-Rendueles, Maria E.R.
RA   Knauf, Jeffrey A.
RA   Haugen, Bryan R.
RA   Fagin, James Alexander
RA   Schweppe, Rebecca E.
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//
RX   PubMed=25675381; DOI=10.1210/jc.2014-2764; PMCID=PMC4422887;
RA   von Roemeling, Christina A.
RA   Marlow, Laura A.
RA   Pinkerton, Anthony B.
RA   Crist, Angela
RA   Miller, James
RA   Tun, Han W.
RA   Smallridge, Robert Christian
RA   Copland, John Alton 3rd
RT   "Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals
RT   stearoyl CoA desaturase 1 as a novel therapeutic target.";
RL   J. Clin. Endocrinol. Metab. 100:E697-E709(2015).
//