ID   B-3
AC   CVCL_6367
AS   CVCL_8482
DR   BTO; BTO:0002221
DR   CLO; CLO_0001812
DR   ATCC; CRL-11421
DR   BioSample; SAMN03471336
DR   Wikidata; Q54752060
RX   Patent=US5643782;
RX   PubMed=8206728;
RX   PubMed=14578405;
CC   Group: Patented cell line.
CC   Problematic cell line: Possibly misidentified. Presence of a Y chromosome in cell line that was thought to be of female origin (STR profile).
CC   Registration: International Depositary Authority, American Type Culture Collection (ATCC); CRL-11421.
CC   Transformant: Ad12-SV40 hybrid virus.
CC   Derived from site: In situ; Eye, ocular lens, epithelium; UBERON=UBERON_0001803.
CC   Cell type: Epithelial cell of ocular lens; CL=CL_0002224.
ST   Source(s): ATCC
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 11
ST   D16S539: 11,12
ST   D5S818: 9,11
ST   D7S820: 11
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 14,19
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   5-12M
CA   Transformed cell line
DT   Created: 04-04-12; Last updated: 29-06-23; Version: 19
RX   Patent=US5643782;
RA   Andley U.P., Fleming T.P.;
RT   "Immortalized epithelial cell lines.";
RL   Patent number US5643782, 01-Jul-1997.
RX   PubMed=8206728;
RA   Andley U.P., Rhim J.S., Chylack L.T. Jr., Fleming T.P.;
RT   "Propagation and immortalization of human lens epithelial cells in
RT   culture.";
RL   Invest. Ophthalmol. Vis. Sci. 35:3094-3102(1994).
RX   PubMed=14578405; DOI=10.1167/iovs.03-0556;
RA   Wang-Su S.-T., McCormack A.L., Yang S.-J., Hosler M.R., Mixon A.,
RA   Riviere M.A., Wilmarth P.A., Andley U.P., Garland D., Li H.,
RA   David L.L., Wagner B.J.;
RT   "Proteome analysis of lens epithelia, fibers, and the HLE B-3 cell
RT   line.";
RL   Invest. Ophthalmol. Vis. Sci. 44:4829-4836(2003).