Cellosaurus logo
expasy logo

Cellosaurus KTC-1 (CVCL_6300)

[Text version]
Cell line name KTC-1
Synonyms KTC1; KTC1naive
Accession CVCL_6300
Resource Identification Initiative To cite this cell line use: KTC-1 (RRID:CVCL_6300)
Comments Population: Japanese.
Doubling time: ~48 hours (PubMed=10946899).
Omics: Array-based CGH.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (PubMed=29156680).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=29156680; PubMed=30737244).
  • Mutation; HGNC; 9801; RAC1; Simple; p.Asp63Val (c.188A>T); Zygosity=Heterozygous (PubMed=30737244).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Heterozygous; Note=In promoter (PubMed=23833040; PubMed=30737244).
Disease Poorly differentiated thyroid gland carcinoma (NCIt: C6040)
Thyroid carcinoma (ORDO: Orphanet_100088)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_A2CS (KTC1res.1)CVCL_A2CT (KTC1res.2)
Sex of cell Male
Age at sampling 68Y
Category Cancer cell line
STR profile Source(s): PubMed=18713817; PubMed=30737244

Markers:
AmelogeninX,Y
CSF1PO10,12
D3S135814,15
D5S81811,12
D7S82011
D8S117911,14
D13S31711
D16S53912
D18S5112,13
D21S1129
FGA23,26
TH019
TPOX11
vWA14,17

Run an STR similarity search on this cell line
Publications

PubMed=10946899; DOI=10.1210/jcem.85.8.6732
Kurebayashi J., Tanaka K., Otsuki T., Moriya T., Kunisue H., Uno M., Sonoo H.
All-trans-retinoic acid modulates expression levels of thyroglobulin and cytokines in a new human poorly differentiated papillary thyroid carcinoma cell line, KTC-1.
J. Clin. Endocrinol. Metab. 85:2889-2896(2000)

CLPUB00144
Kurebayashi J., Tanaka K., Yamamoto Y., Okubo S., Sonoo H.
Human epidermal growth factor receptor 1 and thrombospondin-1 in thyroid cancer.
(In book chapter) Trends in thyroid cancer research. Horizons in cancer research, Vol. 37; Milton C.A. (eds.); pp.89-116; Nova Science Publishers; Hauppauge; USA (2007)

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569
Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. 3rd, Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=25675381; DOI=10.1210/jc.2014-2764; PMCID=PMC4422887
von Roemeling C.A., Marlow L.A., Pinkerton A.B., Crist A., Miller J., Tun H.W., Smallridge R.C., Copland J.A. 3rd
Aberrant lipid metabolism in anaplastic thyroid carcinoma reveals stearoyl CoA desaturase 1 as a novel therapeutic target.
J. Clin. Endocrinol. Metab. 100:E697-E709(2015)

PubMed=29156680; DOI=10.18632/oncotarget.21262; PMCID=PMC5689570
Antonello Z.A., Hsu N., Bhasin M., Roti G., Joshi M., Van Hummelen P., Ye E., Lo A.S., Karumanchi S.A., Bryke C.R., Nucera C.
Vemurafenib-resistance via de novo RBM genes mutations and chromosome 5 aberrations is overcome by combined therapy with palbociclib in thyroid carcinoma with BRAF(V600E).
Oncotarget 8:84743-84760(2017)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line collections (Providers) CLS; 305113
Cell line databases/resources cancercelllines; CVCL_6300
CCRID; 3101HUMSCSP552
Anatomy/cell type resources BTO; BTO:0005144
Encyclopedic resources Wikidata; Q54900619
Polymorphism and mutation databases Cosmic; 683717
Cosmic; 1239967
Cosmic; 2054106
Cosmic; 2755722
IARC_TP53; 21625
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23