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Cellosaurus BHP 10-3 (CVCL_6278)

[Text version]
Cell line name BHP 10-3
Synonyms BHP10-3; BHP-10
Accession CVCL_6278
Resource Identification Initiative To cite this cell line use: BHP 10-3 (RRID:CVCL_6278)
Comments Problematic cell line: Contaminated. Shown to be a TPC-1 derivative (PubMed=18713817; PubMed=20143388).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00179.
Population: Japanese.
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Gene fusion; HGNC; HGNC:18782; CCDC6 + HGNC; HGNC:9967; RET; Name(s)=CCDC6-RET, RET/PTC1 (from parent cell line).
  • Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Ala68fs (c.204_208delGGAGC); Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11355; STAG2; Simple; p.Gln1089Ter (c.3265C>T); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (from parent cell line).
Disease Thyroid gland papillary carcinoma (NCIt: C4035)
Differentiated thyroid carcinoma (ORDO: Orphanet_146)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_6298 (TPC-1)
Sex of cell Female
Age at sampling Adult
Category Cancer cell line
STR profile Source(s): PubMed=18713817

Markers:
AmelogeninX
D3S135816,17
D5S8188,10
D7S82011
D8S117911,17
D13S31711,12
D18S5113,16
D21S1130,31.2
FGA20,21
vWA14,18

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
Publications

PubMed=9253346; DOI=10.1210/jcem.82.8.4136
Ohta K., Pang X.-P., Berg L., Hershman J.M.
Growth inhibition of new human thyroid carcinoma cell lines by activation of adenylate cyclase through the beta-adrenergic receptor.
J. Clin. Endocrinol. Metab. 82:2633-2638(1997)

PubMed=18713817; DOI=10.1210/jc.2008-1102; PMCID=PMC2582569
Schweppe R.E., Klopper J.P., Korch C.T., Pugazhenthi U., Benezra M., Knauf J.A., Fagin J.A., Marlow L.A., Copland J.A. 3rd, Smallridge R.C., Haugen B.R.
Deoxyribonucleic acid profiling analysis of 40 human thyroid cancer cell lines reveals cross-contamination resulting in cell line redundancy and misidentification.
J. Clin. Endocrinol. Metab. 93:4331-4341(2008)

PubMed=20143388; DOI=10.1002/ijc.25242
Capes-Davis A., Theodosopoulos G., Atkin I., Drexler H.G., Kohara A., MacLeod R.A.F., Masters J.R.W., Nakamura Y., Reid Y.A., Reddel R.R., Freshney R.I.
Check your cultures! A list of cross-contaminated or misidentified cell lines.
Int. J. Cancer 127:1-8(2010)

Cross-references
Biological sample resources BioSample; SAMN03151969
Encyclopedic resources Wikidata; Q54796447
Polymorphism and mutation databases Cosmic; 1005449
Cosmic; 1094767
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number26