ID   Akata 2A8
AC   CVCL_6247
SY   2A8
DR   Lonza; 137
DR   Wikidata; Q54749082
RX   PubMed=9593003;
RX   PubMed=10022853;
RX   PubMed=28196595;
WW   https://tcpaportal.org/mclp/
CC   Part of: MD Anderson Cell Lines Project.
CC   Population: Japanese.
CC   Virology: EBV-negative. Treated with hydroxyurea which completely eliminated EBV episomes.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Pro190Leufs*57 (c.569delC); ClinVar=VCV000825904; Zygosity=Unspecified (from parent cell line).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Protein expression by reverse-phase protein arrays.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C27694; EBV-related Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0148 ! Akata
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 18
//
RX   PubMed=9593003; DOI=10.1086/515290;
RA   Chodosh J., Holder V.P., Gan Y.-J., Belgaumi A., Sample J.T.,
RA   Sixbey J.W.;
RT   "Eradication of latent Epstein-Barr virus by hydroxyurea alters the
RT   growth-transformed cell phenotype.";
RL   J. Infect. Dis. 177:1194-1201(1998).
//
RX   PubMed=10022853; DOI=10.1128/mcb.19.3.1651;
RA   Ruf I.K., Rhyne P.W., Yang H., Borza C.M., Hutt-Fletcher L.M.,
RA   Cleveland J.L., Sample J.T.;
RT   "Epstein-Barr virus regulates c-MYC, apoptosis, and tumorigenicity in
RT   Burkitt lymphoma.";
RL   Mol. Cell. Biol. 19:1651-1660(1999).
//
RX   PubMed=28196595; DOI=10.1016/j.ccell.2017.01.005;
RA   Li J., Zhao W., Akbani R., Liu W.-B., Ju Z.-L., Ling S.-Y., Vellano C.P.,
RA   Roebuck P., Yu Q.-H., Eterovic A.K., Byers L.A., Davies M.A., Deng W.-L.,
RA   Gopal Y.N.V., Chen G., von Euw E.M., Slamon D.J., Conklin D.,
RA   Heymach J.V., Gazdar A.F., Minna J.D., Myers J.N., Lu Y.-L., Mills G.B.,
RA   Liang H.;
RT   "Characterization of human cancer cell lines by reverse-phase protein
RT   arrays.";
RL   Cancer Cell 31:225-239(2017).
//