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Cellosaurus A375-R (CVCL_6234)

[Text version]
Cell line name A375-R
Accession CVCL_6234
Resource Identification Initiative To cite this cell line use: A375-R (RRID:CVCL_6234)
Comments Population: Caucasian.
Derived from site: In situ; Leg, skin; UBERON=UBERON_0001511.
Sequence variations
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
Disease Amelanotic melanoma (NCIt: C3802)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0132 (A-375)
Sex of cell Female
Age at sampling 54Y
Category Cancer cell line
Web pages http://www.cells-talk.com/index.php/page/copelibrary?key=A375-R
Publications

PubMed=3260254; DOI=10.4049/jimmunol.141.2.512
Ichinose Y., Bakouche O., Tsao J.Y., Fidler I.J.
Tumor necrosis factor and IL-1 associated with plasma membranes of activated human monocytes lyse monokine-sensitive but not monokine-resistant tumor cells whereas viable activated monocytes lyse both.
J. Immunol. 141:512-518(1988)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6234
Encyclopedic resources Wikidata; Q54606861
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number20