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Cellosaurus SK-MEL-19 (CVCL_6025)

[Text version]
Cell line name SK-MEL-19
Synonyms SK-Mel-19; SKMEL-19; SkMEL-19; SK-MEL19; SK-Mel19; Sk Mel19; SKMEL19; AL-Mel
Accession CVCL_6025
Resource Identification Initiative To cite this cell line use: SK-MEL-19 (RRID:CVCL_6025)
Comments Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
From: Memorial Sloan Kettering Cancer Center; New York; USA.
Characteristics: Pigmented.
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: SNP array analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: Metastatic; Not specified.
Sequence variations
  • Gene deletion; HGNC; 1788; CDKN2B; Zygosity=Heterozygous (PubMed=9598804).
  • Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=17260012; PubMed=21725359; PubMed=24576830; DepMap=ACH-002005).
  • Mutation; HGNC; 1787; CDKN2A; Simple; p.Arg58Ter (c.172C>T) (p.Pro72Leu, c.215C>T); ClinVar=VCV000376310; Zygosity=Homozygous (PubMed=9598804; PubMed=18505964; DepMap=ACH-002005).
  • Mutation; HGNC; 11998; TP53; Simple; p.Asn131Lys (c.393C>A); ClinVar=VCV000246429; Zygosity=Unspecified (DepMap=ACH-002005).
Disease Cutaneous melanoma (NCIt: C3510)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Male
Age at sampling 50Y
Category Cancer cell line
STR profile Source(s): DepMap=ACH-002005

Markers:
AmelogeninX
CSF1PO12
D3S135814,15
D5S81811
D7S82010
D8S117913,15
D13S31711,13
D16S53912
D18S5112
D21S1129
FGA24,25
Penta D12,14
Penta E9,12
TH018,9.3
TPOX9
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=978138; DOI=10.1084/jem.144.4.873; PMCID=PMC2190439
Shiku H., Takahashi T., Oettgen H.F., Old L.J.
Cell surface antigens of human malignant melanoma. II. Serological typing with immune adherence assays and definition of two new surface antigens.
J. Exp. Med. 144:873-881(1976)

PubMed=1067619; DOI=10.1073/pnas.73.9.3278; PMCID=PMC431008
Carey T.E., Takahashi T., Resnick-Silverman L.A., Oettgen H.F., Old L.J.
Cell surface antigens of human malignant melanoma: mixed hemadsorption assays for humoral immunity to cultured autologous melanoma cells.
Proc. Natl. Acad. Sci. U.S.A. 73:3278-3282(1976)

PubMed=833871; DOI=10.1093/jnci/58.2.209
Fogh J., Wright W.C., Loveless J.D.
Absence of HeLa cell contamination in 169 cell lines derived from human tumors.
J. Natl. Cancer Inst. 58:209-214(1977)

PubMed=6933476; DOI=10.1073/pnas.77.7.4260; PMCID=PMC349812
Houghton A.N., Taormina M.C., Ikeda H., Watanabe T., Oettgen H.F., Old L.J.
Serological survey of normal humans for natural antibody to cell surface antigens of melanoma.
Proc. Natl. Acad. Sci. U.S.A. 77:4260-4264(1980)

DOI=10.1007/978-1-4615-7228-2_39
Houghton A.N., Oettgen H.F., Old L.J.
Malignant melanoma. Current status of the search for melanoma-specific antigens.
(In book chapter) Immunodermatology. Comprehensive Immunology, Vol 7; Safai B., Good R.A. (eds.); pp.557-576; Springer; Boston; USA (1981)

PubMed=7017212; DOI=10.1093/jnci/66.6.1003
Pollack M.S., Heagney S.D., Livingston P.O., Fogh J.
HLA-A, B, C and DR alloantigen expression on forty-six cultured human tumor cell lines.
J. Natl. Cancer Inst. 66:1003-1012(1981)

PubMed=7175440; DOI=10.1084/jem.156.6.1755; PMCID=PMC2186870
Houghton A.N., Eisinger M., Albino A.P., Cairncross J.G., Old L.J.
Surface antigens of melanocytes and melanomas. Markers of melanocyte differentiation and melanoma subsets.
J. Exp. Med. 156:1755-1766(1982)

PubMed=6864164; DOI=10.1084/jem.158.1.53; PMCID=PMC2187084
Houghton A.N., Brooks H., Cote R.J., Taormina M.C., Oettgen H.F., Old L.J.
Detection of cell surface and intracellular antigens by human monoclonal antibodies. Hybrid cell lines derived from lymphocytes of patients with malignant melanoma.
J. Exp. Med. 158:53-65(1983)

PubMed=6582512; DOI=10.1073/pnas.81.2.568; PMCID=PMC344720
Mattes M.J., Cordon-Cardo C., Lewis J.L. Jr., Old L.J., Lloyd K.O.
Cell surface antigens of human ovarian and endometrial carcinoma defined by mouse monoclonal antibodies.
Proc. Natl. Acad. Sci. U.S.A. 81:568-572(1984)

PubMed=2983346; DOI=10.1073/pnas.82.5.1470; PMCID=PMC397284
Dracopoli N.C., Houghton A.N., Old L.J.
Loss of polymorphic restriction fragments in malignant melanoma: implications for tumor heterogeneity.
Proc. Natl. Acad. Sci. U.S.A. 82:1470-1474(1985)

PubMed=3518877; DOI=10.3109/07357908609038260
Fogh J.
Human tumor lines for cancer research.
Cancer Invest. 4:157-184(1986)

PubMed=2499655; DOI=10.1084/jem.169.6.2029; PMCID=PMC2189346
Bouchard B., Fuller B.B., Vijayasaradhi S., Houghton A.N.
Induction of pigmentation in mouse fibroblasts by expression of human tyrosinase cDNA.
J. Exp. Med. 169:2029-2042(1989)

PubMed=2784858; DOI=10.1073/pnas.86.8.2804; PMCID=PMC287007
Knuth A., Wolfel T., Klehmann-Hieb E., Boon T., Meyer zum Buschenfelde K.-H.
Cytolytic T-cell clones against an autologous human melanoma: specificity study and definition of three antigens by immunoselection.
Proc. Natl. Acad. Sci. U.S.A. 86:2804-2808(1989)

PubMed=9598804; DOI=10.1002/(SICI)1098-2264(199806)22:2<157::AID-GCC11>3.0.CO;2-N
Walker G.J., Flores J.F., Glendening J.M., Lin A.H.-T., Markl I.D.C., Fountain J.W.
Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.
Genes Chromosomes Cancer 22:157-163(1998)

PubMed=17260012; DOI=10.1038/sj.onc.1210252
Jonsson G., Dahl C., Staaf J., Sandberg T., Bendahl P.-O., Ringner M., Guldberg P., Borg A.
Genomic profiling of malignant melanoma using tiling-resolution arrayCGH.
Oncogene 26:4738-4748(2007)

PubMed=18505964; DOI=10.1093/jnci/djn157; PMCID=PMC4410798
Freedberg D.E., Rigas S.H., Russak J.E., Gai W.-M., Kaplow M.E., Osman I., Turner F., Randerson-Moor J.A., Houghton A.N., Busam K.J., Bishop D.T., Bastian B.C., Newton-Bishop J.A., Polsky D.
Frequent p16-independent inactivation of p14ARF in human melanoma.
J. Natl. Cancer Inst. 100:784-795(2008)

PubMed=21343389; DOI=10.1158/0008-5472.CAN-10-2958; PMCID=PMC3070783
Rose A.E., Poliseno L., Wang J.-H., Clark M., Pearlman A., Wang G.-M., Vega y Saenz de Miera E.C., Medicherla R., Christos P.J., Shapiro R., Pavlick A., Darvishian F., Zavadil J., Polsky D., Hernando E., Ostrer H., Osman I.
Integrative genomics identifies molecular alterations that challenge the linear model of melanoma progression.
Cancer Res. 71:2561-2571(2011)

PubMed=21725359; DOI=10.1038/onc.2011.250; PMCID=PMC3267014
Xing F., Persaud Y., Pratilas C.A., Taylor B.S., Janakiraman M., She Q.-B., Gallardo H.F., Liu C., Merghoub T., Hefter B.E., Dolgalev I., Viale A.J., Heguy A., de Stanchina E., Cobrinik D., Bollag G., Wolchok J.D., Houghton A.N., Solit D.B.
Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.
Oncogene 31:446-457(2012)

PubMed=24576830; DOI=10.1158/0008-5472.CAN-13-2625; PMCID=PMC4005042
Nissan M.H., Pratilas C.A., Jones A.M., Ramirez R., Won H., Liu C.-L., Tiwari S., Kong L., Hanrahan A.J., Yao Z., Merghoub T., Ribas A., Chapman P.B., Yaeger R., Taylor B.S., Schultz N., Berger M.F., Rosen N., Solit D.B.
Loss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.
Cancer Res. 74:2340-2350(2014)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6025
Cell_Model_Passport; SIDM01423
DepMap; ACH-002005
Lonza; 1332
Chemistry resources ChEMBL-Cells; CHEMBL3307448
ChEMBL-Targets; CHEMBL614915
PubChem_Cell_line; CVCL_6025
Encyclopedic resources Wikidata; Q54953894
Gene expression databases GEO; GSM156032
GEO; GSM555122
GEO; GSM555175
GEO; GSM784508
Polymorphism and mutation databases Cosmic; 685202
Cosmic; 721841
Cosmic; 886830
Cosmic; 923385
Cosmic; 933126
Cosmic; 1047686
Cosmic; 1060427
Cosmic; 1122255
Cosmic; 1669136
IARC_TP53; 26112
Progenetix; CVCL_6025
Entry history
Entry creation04-Apr-2012
Last entry update10-Sep-2024
Version number35