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Cellosaurus OCUT-1 (CVCL_6017)

[Text version]
Cell line name OCUT-1
Synonyms Ocut-1; OCUT1; Osaka City University Thyroid-1
Accession CVCL_6017
Resource Identification Initiative To cite this cell line use: OCUT-1 (RRID:CVCL_6017)
Comments Population: Japanese.
Doubling time: 34 hours (PubMed=12210034).
Omics: Transcriptome analysis by microarray.
Miscellaneous: Cell line has been lost (PubMed=24357248).
Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
Sequence variations
  • Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=23833040; PubMed=30737244).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=30737244).
  • Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Homozygous; Note=In promoter (PubMed=23833040).
Disease Thyroid gland anaplastic carcinoma (NCIt: C3878)
Anaplastic thyroid carcinoma (ORDO: Orphanet_142)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Children:
CVCL_B5GE (OCUT-1C)CVCL_B5GF (OCUT-1F)
Sex of cell Female
Age at sampling 74Y
Category Cancer cell line
STR profile Source(s): PubMed=30737244

Markers:
AmelogeninX
CSF1PO12,13
D3S135815
D5S8189,13
D7S82011,13
D8S117915,17
D13S3178
D16S53910,12
D18S5119,20
D21S1130
FGA21,22
TH016,9
TPOX8,11
vWA16,18

Run an STR similarity search on this cell line
Publications

PubMed=12210034; DOI=10.1002/jso.10122
Ogisawa K., Onoda N., Ishikawa T., Takenaka C., Inaba M., Ogawa Y., Chung K.H.-Y.S.
Establishment and characterization of OCUT-1, an undifferentiated thyroid cancer cell line expressing high level of telomerase.
J. Surg. Oncol. 80:197-203(2002)

PubMed=23833040; DOI=10.1210/jc.2013-2383; PMCID=PMC3763971
Landa I., Ganly I., Chan T.A., Mitsutake N., Matsuse M., Ibrahimpasic T., Ghossein R.A., Fagin J.A.
Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease.
J. Clin. Endocrinol. Metab. 98:E1562-E1566(2013)

PubMed=24357248; DOI=10.1007/s00268-013-2409-7
Onoda N., Nakamura M., Aomatsu N., Noda S., Kashiwagi S., Hirakawa K.
Establishment, characterization and comparison of seven authentic anaplastic thyroid cancer cell lines retaining clinical features of the original tumors.
World J. Surg. 38:688-695(2014)

PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280
Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C., Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N., Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R., Fagin J.A., Schweppe R.E.
Comprehensive genetic characterization of human thyroid cancer cell lines: a validated panel for preclinical studies.
Clin. Cancer Res. 25:3141-3151(2019)

Cross-references
Cell line databases/resources cancercelllines; CVCL_6017
Anatomy/cell type resources BTO; BTO_0004846
Encyclopedic resources Wikidata; Q54931845
Polymorphism and mutation databases Cosmic; 1152123
Cosmic; 1239960
Cosmic; 1280045
Cosmic; 1507372
Cosmic; 1533548
Cosmic; 1536125
Cosmic; 1889003
Cosmic; 2054107
Cosmic; 2319852
Cosmic; 2791081
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number21