Cellosaurus cell line Adult/T315I (CVCL

Cross-references
Cell line name	Adult/T315I
Accession	CVCL_5K96
Resource Identification Initiative	To cite this cell line use: Adult/T315I (RRID:CVCL_5K96)
Sequence variations	Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL (PubMed=21474579). Mutation; HGNC; HGNC:76; ABL1; Simple; p.Thr315Ile (c.944C>T) (c.1001C>T); ClinVar=VCV000012624; Zygosity=Unspecified (PubMed=21474579).
Disease	Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174) Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin	Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell	Sex unspecified
Age at sampling	Adult
Category	Cancer cell line
Publications	PubMed=21474579; DOI=10.1158/1078-0432.CCR-11-0234; PMCID=PMC3096723 Nguyen T., Dai Y., Attkisson E., Kramer L., Jordan N., Nguyen N., Kolluri N., Muschen M., Grant S. HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo. Clin. Cancer Res. 17:3219-3232(2011)
Cell line databases/resources	cancercelllines; CVCL_5K96
Encyclopedic resources	Wikidata; Q54608870
Entry history
Entry creation	14-Dec-2015
Last entry update	19-Dec-2024
Version number	12