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Cellosaurus BV-173/E255K (CVCL_5K95)

[Text version]
Cell line name BV-173/E255K
Synonyms BV173/E255K
Accession CVCL_5K95
Resource Identification Initiative To cite this cell line use: BV-173/E255K (RRID:CVCL_5K95)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_45783; Imatinib (Gleevec; STI571).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
  • Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 13 fused to ABL1 exon 2 (b2a2 transcript) (from parent cell line).
  • Mutation; HGNC; HGNC:76; ABL1; Simple; p.Glu255Lys (c.763G>A); ClinVar=VCV000376090; Zygosity=Unspecified (PubMed=21474579).
  • Mutation; HGNC; HGNC:7133; KMT2D; Simple; p.Gln4045Ter (c.12133C>T); Zygosity=Heterozygous (from parent cell line).
Disease Chronic myelogenous leukemia, BCR-ABL1 positive (NCIt: C3174)
Chronic myeloid leukemia (ORDO: Orphanet_521)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0181 (BV-173)
Sex of cell Male
Age at sampling 45Y
Category Cancer cell line
Publications

PubMed=21474579; DOI=10.1158/1078-0432.CCR-11-0234; PMCID=PMC3096723
Nguyen T., Dai Y., Attkisson E., Kramer L., Jordan N., Nguyen N., Kolluri N., Muschen M., Grant S.
HDAC inhibitors potentiate the activity of the BCR/ABL kinase inhibitor KW-2449 in imatinib-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.
Clin. Cancer Res. 17:3219-3232(2011)

Cross-references
Cell line collections (Providers) Kerafast; EVC001
Cell line databases/resources cancercelllines; CVCL_5K95
Encyclopedic resources Wikidata; Q54798655
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number18