Cellosaurus TH1 (CVCL_5J51)
| Cell line name | TH1 |
|---|---|
| Accession | CVCL_5J51 |
| Resource Identification Initiative | To cite this cell line use: TH1 (RRID:CVCL_5J51) |
| Comments | Group: Patented cell line. Characteristics: Reversible immortalized. The transduced hTERT and SV40 Tag genes are flanked by loxP sites. Transient Cre expression in this cell line leads to deletion of the two genes thus leading to a decrease in the rate of cell proliferation and ultimately to cell senescence (PubMed=15208689). Doubling time: 40-48 hours (PubMed=15208689). Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT. Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen. Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo. Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40). Derived from site: In situ; Kidney, proximal tubule; UBERON=UBERON_0004134. Cell type: Epithelial cell of proximal tubule; CL=CL_0002306. |
| Species of origin | Homo sapiens (Human) (NCBI Taxonomy: 9606) |
| Originate from same individual | CVCL_5J52 ! TH7 |
| Sex of cell | Sex unspecified |
| Age at sampling | Age unspecified |
| Category | Transformed cell line |
| Publications | PubMed=15208689; DOI=10.1038/sj.onc.1207801 Patent=US20050136539 |
| Cross-references | |
| Cell line collections (Providers) | Kerafast; ECH001 |
| Encyclopedic resources | Wikidata; Q54972283 |
| Entry history | |
| Entry creation | 14-Dec-2015 |
| Last entry update | 19-Dec-2024 |
| Version number | 13 |