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Cellosaurus MCF-7/VP (CVCL_5I65)

[Text version]
Cell line name MCF-7/VP
Synonyms MCF7-VP; MCF7/VP; MCF-7 VP-16; MCF-7/VP16; MCF7-VP16
Accession CVCL_5I65
Resource Identification Initiative To cite this cell line use: MCF-7/VP (RRID:CVCL_5I65)
Comments Population: Caucasian.
Doubling time: 47 hours (PubMed=8562478).
Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; 4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; 8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0031 (MCF-7)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
Publications

PubMed=7903202
Schneider E., Horton J.K., Yang C.-H., Nakagawa M., Cowan K.H.
Multidrug resistance-associated protein gene overexpression and reduced drug sensitivity of topoisomerase II in a human breast carcinoma MCF7 cell line selected for etoposide resistance.
Cancer Res. 54:152-158(1994)

PubMed=8562478
Wosikowski K., Regis J.T., Robey R.W., Alvarez M., Buters J.T.M., Gudas J.M., Bates S.E.
Normal p53 status and function despite the development of drug resistance in human breast cancer cells.
Cell Growth Differ. 6:1395-1403(1995)

PubMed=11406094; DOI=10.1016/S0005-2736(01)00308-X
Robey R.W., Honjo Y., van de Laar A., Miyake K., Regis J.T., Litman T., Bates S.E.
A functional assay for detection of the mitoxantrone resistance protein, MXR (ABCG2).
Biochim. Biophys. Acta 1512:171-182(2001)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5I65
Chemistry resources ChEMBL-Cells; CHEMBL3307299
ChEMBL-Targets; CHEMBL614128
ChEMBL-Targets; CHEMBL614329
PubChem_Cell_line; CVCL_5I65
Encyclopedic resources Wikidata; Q54904398
Entry history
Entry creation14-Dec-2015
Last entry update05-Oct-2023
Version number14