Cell line name |
CCRF-CEM/MTX140-LV |
Synonyms |
CEM/MTX140LV |
Accession |
CVCL_5H83 |
Resource Identification Initiative |
To cite this cell line use: CCRF-CEM/MTX140-LV (RRID:CVCL_5H83) |
Comments |
Population: Caucasian. Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX). Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178. Cell type: T-cell; CL=CL_0000084. |
Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953) Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
Hierarchy |
Parent: CVCL_0207 (CCRF-CEM) |
Sex of cell |
Female |
Age at sampling |
3Y11M |
Category |
Cancer cell line |
Publications | PubMed=9369939; DOI=10.1111/j.1349-7006.1997.tb00467.x; PMCID=PMC5921512 Miyachi H., Takemura Y., Kobayashi H., Ando Y. Cytotoxicity of trimetrexate against antifolate-resistant human T-cell leukemia cell lines developed in oxidized or reduced folate. Jpn. J. Cancer Res. 88:900-906(1997) PubMed=12482398; DOI=10.1006/bcmd.2002.0530 Efferth T., Verdorfer I., Miyachi H., Sauerbrey A., Drexler H.G., Chitambar C.R., Haber M., Gebhart E. Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines. Blood Cells Mol. Dis. 29:1-13(2002) |
Cross-references |
Cell line databases/resources |
cancercelllines; CVCL_5H83
|
Encyclopedic resources |
Wikidata; Q54809029
|
Entry history |
Entry creation | 14-Dec-2015 |
Last entry update | 19-Dec-2024 |
Version number | 17 |
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