| Cell line name |
CCRF-CEM/MTX R1 |
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| Synonyms |
CEM/MTX R1; CEM/MTXR1 |
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| Accession |
CVCL_5H80 |
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| Resource Identification Initiative |
To cite this cell line use: CCRF-CEM/MTX R1 (RRID:CVCL_5H80) |
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| Comments |
Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_44185; Methotrexate (MTX).
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Cell type: T-cell; CL=CL_0000084. |
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| Sequence variations |
- Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
- Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
- Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
|
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| Disease |
Childhood T acute lymphoblastic leukemia (NCIt: C7953)
Precursor T-cell acute lymphoblastic leukemia (ORDO: Orphanet_99861) |
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| Species of origin |
Homo sapiens (Human)
(NCBI Taxonomy: 9606) |
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| Hierarchy |
Parent: CVCL_0207 (CCRF-CEM) |
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| Sex of cell |
Female |
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| Age at sampling |
3Y11M |
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| Category |
Cancer cell line |
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| Publications | PubMed=2754745; DOI=10.1093/jnci/81.16.1250
Haber M., Reed C., Kavallaris M., Norris M.D., Stewart B.W.
Resistance to drugs associated with the multidrug resistance phenotype following selection with high-concentration methotrexate.
J. Natl. Cancer Inst. 81:1250-1254(1989) PubMed=12482398; DOI=10.1006/bcmd.2002.0530
Efferth T., Verdorfer I., Miyachi H., Sauerbrey A., Drexler H.G., Chitambar C.R., Haber M., Gebhart E.
Genomic imbalances in drug-resistant T-cell acute lymphoblastic CEM leukemia cell lines.
Blood Cells Mol. Dis. 29:1-13(2002) |
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| Cross-references |
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| Cell line databases/resources |
cancercelllines; CVCL_5H80
|
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| Encyclopedic resources |
Wikidata; Q54809025
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| Entry history |
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| Entry creation | 14-Dec-2015 |
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| Last entry update | 19-Dec-2024 |
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| Version number | 17 |
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