ID   PUC4-2
AC   CVCL_5A62
DR   Wikidata; Q54948694
RX   PubMed=220255;
RX   PubMed=2595452;
CC   Selected for resistance to: ChEBI; CHEBI:35668; 6-azauridine (6AUR).
CC   Selected for resistance to: ChEBI; CHEBI:90284; Pyrazofurin (PF).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Leu133Gln (c.398T>A); Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; UniProtKB; O09185; Tp53; Simple; p.Cys135Trp (c.405C>G); Zygosity=Unspecified (from parent cell line).
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
CC   Cell type: Fibroblast of lung; CL=CL_0002553.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_5A61 ! V79 A3
SX   Male
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 14-12-15; Last updated: 29-06-23; Version: 9
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RX   PubMed=220255; DOI=10.1016/S0021-9258(17)30053-4;
RA   Suttle D.P., Stark G.R.;
RT   "Coordinate overproduction of orotate phosphoribosyltransferase and
RT   orotidine-5'-phosphate decarboxylase in hamster cells resistant to
RT   pyrazofurin and 6-azauridine.";
RL   J. Biol. Chem. 254:4602-4607(1979).
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RX   PubMed=2595452; DOI=10.1007/BF01534911;
RA   Qumsiyeh M.B., Suttle D.P.;
RT   "Cytogenetic analysis of amplification and deamplification of UMP
RT   synthase genes in Chinese hamster cells.";
RL   Somat. Cell Mol. Genet. 15:503-512(1989).
//