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Cellosaurus CHO-xrs-4 (CVCL_5A39)

[Text version]
Cell line name CHO-xrs-4
Synonyms xrs-4; xrs4
Accession CVCL_5A39
Resource Identification Initiative To cite this cell line use: CHO-xrs-4 (RRID:CVCL_5A39)
Comments Characteristics: Sensitive to X-ray. Has a defect in double-strand break rejoining (PubMed=6513971).
Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
Cell type: Epithelial cell of ovary; CL=CL_2000064.
Species of origin Cricetulus griseus (Chinese hamster) (Cricetulus barabensis griseus) (NCBI Taxonomy: 10029)
Hierarchy Parent: CVCL_0214 (CHO-K1)
Sex of cell Female
Age at sampling Adult
Category Spontaneously immortalized cell line
Publications

PubMed=6197643; DOI=10.1016/0167-8817(83)90026-3
Jeggo P.A., Kemp L.M.
X-ray-sensitive mutants of Chinese hamster ovary cell line. Isolation and cross-sensitivity to other DNA-damaging agents.
Mutat. Res. 112:313-327(1983)

PubMed=6513971; DOI=10.1016/0167-8817(84)90037-3
Kemp L.M., Sedgwick S.G., Jeggo P.A.
X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining.
Mutat. Res. 132:189-196(1984)

PubMed=2564870; DOI=10.1080/09553008914550651
Denekamp J., Whitmore G.F., Jeggo P.A.
Biphasic survival curves for XRS radiosensitive cells: subpopulations or transient expression of repair competence?
Int. J. Radiat. Biol. 55:605-617(1989)

PubMed=9032253; DOI=10.1128/mcb.17.3.1264; PMCID=PMC231851
Singleton B.K., Priestley A., Steingrimsdottir H., Gell D., Blunt T., Jackson S.P., Lehmann A.R., Jeggo P.A.
Molecular and biochemical characterization of xrs mutants defective in Ku80.
Mol. Cell. Biol. 17:1264-1273(1997)

Cross-references
Encyclopedic resources Wikidata; Q54813130
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number8