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Cellosaurus MCF-7/LetR-1 (CVCL_5A17)

[Text version]
Cell line name MCF-7/LetR-1
Synonyms MCF7/LetR-1; MCF-7/S0.5/LetR-1; LetR-1
Accession CVCL_5A17
Resource Identification Initiative To cite this cell line use: MCF-7/LetR-1 (RRID:CVCL_5A17)
Comments Population: Caucasian.
Selected for resistance to: ChEBI; CHEBI_6413; Letrozole.
Derived from site: Metastatic; Pleural effusion; UBERON=UBERON_0000175.
Sequence variations
  • Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
  • Mutation; HGNC; HGNC:4172; GATA3; Simple; p.Asp336Glyfs*17 (c.1006dupG); Zygosity=Heterozygous (from parent cell line).
  • Mutation; HGNC; HGNC:8975; PIK3CA; Simple; p.Glu545Lys (c.1633G>A); ClinVar=VCV000013655; Zygosity=Heterozygous (from parent cell line).
Disease Invasive breast carcinoma of no special type (NCIt: C4194)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_1D47 (MCF-7/S0.5)
Sex of cell Female
Age at sampling 69Y
Category Cancer cell line
STR profile Source(s): ECACC=16022524

Markers:
AmelogeninX
CSF1PO10
D3S135816
D5S81811,12
D7S8209
D8S117910,14
D13S31711
D16S53911,12
D18S5114
D21S1130
FGA23,25
Penta D12
Penta E7,12
TH016
TPOX9,12
vWA14,15

Run an STR similarity search on this cell line
Publications

PubMed=25625755; DOI=10.3892/ijo.2015.2850; PMCID=PMC4356498
Hole S., Pedersen A.M., Hansen S.K., Lundqvist J., Yde C.W., Lykkesfeldt A.E.
New cell culture model for aromatase inhibitor-resistant breast cancer shows sensitivity to fulvestrant treatment and cross-resistance between letrozole and exemestane.
Int. J. Oncol. 46:1481-1490(2015)

PubMed=25667100; DOI=10.1007/s10549-015-3284-8
Hole S., Pedersen A.M., Lykkesfeldt A.E., Yde C.W.
Aurora kinase A and B as new treatment targets in aromatase inhibitor-resistant breast cancer cells.
Breast Cancer Res. Treat. 149:715-726(2015)

Cross-references
Cell line collections (Providers) CancerTools; 152547
ECACC; 16022524 - Discontinued
Ximbio; 152547
Cell line databases/resources cancercelllines; CVCL_5A17
Encyclopedic resources Wikidata; Q54904369
Entry history
Entry creation14-Dec-2015
Last entry update19-Dec-2024
Version number18