ID   KB-ChR-8-5-11
AC   CVCL_5997
SY   KB-8-5-11
DR   Wikidata; Q54899553
RX   PubMed=3711108;
RX   PubMed=3856953;
RX   PubMed=24403508;
CC   Problematic cell line: Contaminated. Ancestral cell line (KB) has been shown to be a HeLa derivative.
CC   Population: African American.
CC   Characteristics: Resistant to paclitaxel and many other chemotherapy agents as it overexpresses the P-glycoprotein (ABCB1).
CC   Selected for resistance to: ChEBI; CHEBI:23359; Colchicine.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_5994 ! KB-ChR-8-5
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 18
RX   PubMed=3711108; DOI=10.1016/S0021-9258(19)57466-X;
RA   Shen D.-W., Cardarelli C., Hwang J., Cornwell M., Richert N., Ishii S.,
RA   Pastan I., Gottesman M.M.;
RT   "Multiple drug-resistant human KB carcinoma cells independently
RT   selected for high-level resistance to colchicine, adriamycin, or
RT   vinblastine show changes in expression of specific proteins.";
RL   J. Biol. Chem. 261:7762-7770(1986).
RX   PubMed=3856953; DOI=10.1007/BF01534700;
RA   Akiyama S.-i., Fojo A.T., Hanover J.A., Pastan I., Gottesman M.M.;
RT   "Isolation and genetic characterization of human KB cell lines
RT   resistant to multiple drugs.";
RL   Somat. Cell Mol. Genet. 11:117-126(1985).
RX   PubMed=24403508;
RA   Doherty B., Lawlor D., Gillet J.-P., Gottesman M.M., O'Leary J.J.,
RA   Stordal B.;
RT   "Collateral sensitivity to cisplatin in KB-8-5-11 drug-resistant
RT   cancer cells.";
RL   Anticancer Res. 34:503-507(2014).