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Cellosaurus JHU-028 (CVCL_5992)

[Text version]
Cell line name JHU-028
Synonyms JHU 028; JHU028; SCC028; HNSCC 028; O28; Johns Hopkins University-028
Accession CVCL_5992
Resource Identification Initiative To cite this cell line use: JHU-028 (RRID:CVCL_5992)
Comments Problematic cell line: Contaminated. Shown to be a A-549 derivative (PubMed=21868764). Originally thought to originate from a base of tongue squamous cell carcinoma.
Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00406.
Population: Caucasian.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by microarray.
Derived from site: In situ; Lung; UBERON=UBERON_0002048.
Sequence variations
  • Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000012584; Zygosity=Homozygous (DepMap).
  • Mutation; HGNC; 11389; STK11; Simple; p.Gln37Ter (c.109C>T); ClinVar=VCV000376334; Zygosity=Homozygous (DepMap).
Disease Lung adenocarcinoma (NCIt: C3512)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Hierarchy Parent: CVCL_0023 (A-549)
Sex of cell Male
Age at sampling 58Y
Category Cancer cell line
STR profile Source(s): PubMed=21868764

Markers:
AmelogeninX
CSF1PO10,12
D5S81813
D7S8208,11
D13S31711
D16S53911,12
TH018
TPOX8,11
vWA14

Run an STR similarity search on this cell line
Web pages https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
Publications

PubMed=12925955; DOI=10.1002/ijc.11341
Minhas K.M., Singh B., Jiang W.-W., Sidransky D., Califano J.A. III
Spindle assembly checkpoint defects and chromosomal instability in head and neck squamous cell carcinoma.
Int. J. Cancer 107:46-52(2003)

PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6
Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E., Sidransky D.
PUMA in head and neck cancer.
Cancer Lett. 199:75-81(2003)

PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690
Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C., Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G., Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.
Assembly and initial characterization of a panel of 85 genomically validated cell lines from diverse head and neck tumor sites.
Clin. Cancer Res. 17:7248-7264(2011)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5992
Cell_Model_Passport; SIDM00902
DepMap; ACH-002337
Anatomy/cell type resources BTO; BTO:0006404
Biological sample resources BioSample; SAMN03151610
Chemistry resources GDSC; 1298154
PharmacoDB; JHU028_696_2019
Encyclopedic resources Wikidata; Q54898675
Gene expression databases ArrayExpress; E-MTAB-3610
Proteomic databases PRIDE; PXD002132
Sequence databases EGA; EGAS00001000978
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number23