ID   JHU-019
AC   CVCL_5989
SY   JHU 019; JHU-O19; JHU019; O19; 019; 19
DR   BTO; BTO:0003889
DR   ATCC; CRL-2721
DR   BioSample; SAMN03151893
DR   BioSample; SAMN03471776
DR   PharmacoDB; JHU019_694_2019
DR   Wikidata; Q54898670
RX   PubMed=12925955;
RX   PubMed=12963126;
RX   PubMed=21868764;
CC   Problematic cell line: Contaminated. Shown to be a PC-3 derivative (PubMed=21868764). Originally thought to originate from a 58 year old female patient with oropharyngeal squamous cell carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00405.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Lys139Argfs*31 (c.414delC) (413delC); ClinVar=VCV000133281; Zygosity=Homozygous (from parent cell line).
CC   Discontinued: ATCC; CRL-2721; true.
CC   Derived from metastatic site: Bone.
ST   Source(s): ATCC; PubMed=21868764
ST   Amelogenin: X
ST   CSF1PO: 11
ST   D13S317: 11
ST   D16S539: 11
ST   D5S818: 9,13 (ATCC)
ST   D5S818: 13 (PubMed=21868764)
ST   D7S820: 8,11
ST   TH01: 6,7
ST   TPOX: 8,9
ST   vWA: 17
DI   NCIt; C4863; Prostate carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0035 ! PC-3
SX   Male
AG   62Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 21-03-23; Version: 22
RX   PubMed=12925955; DOI=10.1002/ijc.11341;
RA   Minhas K.M., Singh B., Jiang W.-W., Sidransky D., Califano J.A. III;
RT   "Spindle assembly checkpoint defects and chromosomal instability in
RT   head and neck squamous cell carcinoma.";
RL   Int. J. Cancer 107:46-52(2003).
RX   PubMed=12963126; DOI=10.1016/S0304-3835(03)00344-6;
RA   Hoque M.O., Begum S., Sommer M., Lee T., Trink B., Ratovitski E.,
RA   Sidransky D.;
RT   "PUMA in head and neck cancer.";
RL   Cancer Lett. 199:75-81(2003).
RX   PubMed=21868764; DOI=10.1158/1078-0432.CCR-11-0690;
RA   Zhao M., Sano D., Pickering C.R., Jasser S.A., Henderson Y.C.,
RA   Clayman G.L., Sturgis E.M., Ow T.J., Lotan R., Carey T.E., Sacks P.G.,
RA   Grandis J.R., Sidransky D., Heldin N.-E., Myers J.N.;
RT   "Assembly and initial characterization of a panel of 85 genomically
RT   validated cell lines from diverse head and neck tumor sites.";
RL   Clin. Cancer Res. 17:7248-7264(2011).