ID   UM-SCV-7
AC   CVCL_5977
SY   UMSCV-7; University of Michigan-Squamous cell Carcinoma of the Vulva-7
DR   cancercelllines; CVCL_5977
DR   IARC_TP53; 6931
DR   Wikidata; Q54990967
RX   PubMed=7503188;
RX   PubMed=7599042;
RX   PubMed=9887230;
RX   PubMed=15047230;
RX   PubMed=17178626;
CC   Doubling time: 37 hours (PubMed=15047230).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Gly245Ser (c.733G>A); ClinVar=VCV000012365; Zygosity=Unspecified (PubMed=7503188; PubMed=9887230).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg249Serfs*95 (c.747delG); Zygosity=Unspecified (PubMed=7503188; PubMed=9887230).
CC   Derived from site: In situ; Vulva; UBERON=UBERON_0000997.
DI   NCIt; C4052; Vulvar squamous cell carcinoma
DI   ORDO; Orphanet_494448; Vulvar squamous cell carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   77Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 19-12-24; Version: 22
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RX   PubMed=7503188; DOI=10.1016/0002-9378(95)90636-3;
RA   Hietanen S.H., Kurvinen K., Syrjanen K.J., Grenman S.E., Carey T.E.,
RA   McClatchey K.D., Syrjanen S.M.;
RT   "Mutation of tumor suppressor gene p53 is frequently found in vulvar
RT   carcinoma cells.";
RL   Am. J. Obstet. Gynecol. 173:1477-1482(1995).
//
RX   PubMed=7599042; DOI=10.1038/bjc.1995.289; PMCID=PMC2034151;
RA   Hietanen S.H., Grenman S.E., Syrjanen K.J., Lappalainen K., Kauppinen J.,
RA   Carey T.E., Syrjanen S.M.;
RT   "Human papillomavirus in vulvar and vaginal carcinoma cell lines.";
RL   Br. J. Cancer 72:134-139(1995).
//
RX   PubMed=9887230; DOI=10.1006/gyno.1998.5194;
RA   Rantanen V., Grenman S.E., Kurvinen K., Hietanen S.H., Raitanen M.,
RA   Syrjanen S.M.;
RT   "p53 mutations and presence of HPV DNA do not correlate with
RT   radiosensitivity of gynecological cancer cell lines.";
RL   Gynecol. Oncol. 71:352-358(1998).
//
RX   PubMed=15047230; DOI=10.1016/j.ygyno.2003.12.033;
RA   Raitanen M., Worsham M.J., Lakkala T., Carey T.E., Van Dyke D.L.,
RA   Grenman R., Klemi P., Rantanen V., Isola J.J., Grenman S.E.;
RT   "Characterization of 10 vulvar carcinoma cell lines by karyotyping,
RT   comparative genomic hybridization and flow cytometry.";
RL   Gynecol. Oncol. 93:155-163(2004).
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RX   PubMed=17178626; DOI=10.1080/09553000600969812;
RA   Kurvinen K., Rantanen V., Syrjanen S.M., Johansson B.;
RT   "Radiation-induced effects on telomerase in gynecological cancer cell
RT   lines with different radiosensitivity and repair capacity.";
RL   Int. J. Radiat. Biol. 82:859-867(2006).
//