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Cellosaurus UM-SCV-2 (CVCL_5974)

[Text version]
Cell line name UM-SCV-2
Synonyms UMSCV-2; University of Michigan-Squamous cell Carcinoma of the Vulva-2
Accession CVCL_5974
Resource Identification Initiative To cite this cell line use: UM-SCV-2 (RRID:CVCL_5974)
Comments Doubling time: 58 hours (PubMed=15047230).
Derived from site: In situ; Vulva; UBERON=UBERON_0000997.
Sequence variations
Disease Vulvar squamous cell carcinoma (NCIt: C4052)
Vulvar squamous cell carcinoma (ORDO: Orphanet_494448)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Sex of cell Female
Age at sampling 86Y
Category Cancer cell line
Publications

PubMed=2758419
Pekkola-Heino K., Kulmala J., Grenman S.E., Carey T.E., Grenman R.
Radiation response of vulvar squamous cell carcinoma (UM-SCV-1A, UM-SCV-1B, UM-SCV-2, and A-431) cells in vitro.
Cancer Res. 49:4876-4878(1989)

PubMed=1777413; DOI=10.1002/gcc.2870030604
Worsham M.J., Van Dyke D.L., Grenman S.E., Grenman R., Hopkins M.P., Roberts J.A., Gasser K.M., Schwartz D.R., Carey T.E.
Consistent chromosome abnormalities in squamous cell carcinoma of the vulva.
Genes Chromosomes Cancer 3:420-432(1991)

PubMed=1958593; DOI=10.1002/gcc.2870030406
Bradford C.R., Kimmel K.A., Van Dyke D.L., Worsham M.J., Tilley B.J., Burk D., del Rosario F., Lutz S., Tooley R., Hayashida D.J.S., Carey T.E.
11p deletions and breakpoints in squamous cell carcinoma: association with altered reactivity with the UM-E7 antibody.
Genes Chromosomes Cancer 3:272-282(1991)

PubMed=7503188; DOI=10.1016/0002-9378(95)90636-3
Hietanen S.H., Kurvinen K., Syrjanen K.J., Grenman S.E., Carey T.E., McClatchey K.D., Syrjanen S.M.
Mutation of tumor suppressor gene p53 is frequently found in vulvar carcinoma cells.
Am. J. Obstet. Gynecol. 173:1477-1482(1995)

PubMed=7599042; DOI=10.1038/bjc.1995.289; PMCID=PMC2034151
Hietanen S.H., Grenman S.E., Syrjanen K.J., Lappalainen K., Kauppinen J., Carey T.E., Syrjanen S.M.
Human papillomavirus in vulvar and vaginal carcinoma cell lines.
Br. J. Cancer 72:134-139(1995)

PubMed=8646696; DOI=10.1002/(SICI)1097-0142(19960501)77:9<1940::AID-CNCR26>3.0.CO;2-Z
Jaakkola M., Rantanen V., Grenman S.E., Kulmala J., Grenman R.
In vitro concurrent paclitaxel and radiation of four vulvar squamous cell carcinoma cell lines.
Cancer 77:1940-1946(1996)

PubMed=9887230; DOI=10.1006/gyno.1998.5194
Rantanen V., Grenman S.E., Kurvinen K., Hietanen S.H., Raitanen M., Syrjanen S.M.
p53 mutations and presence of HPV DNA do not correlate with radiosensitivity of gynecological cancer cell lines.
Gynecol. Oncol. 71:352-358(1998)

PubMed=15047230; DOI=10.1016/j.ygyno.2003.12.033
Raitanen M., Worsham M.J., Lakkala T., Carey T.E., Van Dyke D.L., Grenman R., Klemi P., Rantanen V., Isola J.J., Grenman S.E.
Characterization of 10 vulvar carcinoma cell lines by karyotyping, comparative genomic hybridization and flow cytometry.
Gynecol. Oncol. 93:155-163(2004)

PubMed=17178626; DOI=10.1080/09553000600969812
Kurvinen K., Rantanen V., Syrjanen S.M., Johansson B.
Radiation-induced effects on telomerase in gynecological cancer cell lines with different radiosensitivity and repair capacity.
Int. J. Radiat. Biol. 82:859-867(2006)

Cross-references
Cell line databases/resources cancercelllines; CVCL_5974
Encyclopedic resources Wikidata; Q54990961
Polymorphism and mutation databases IARC_TP53; 6926
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number21