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Cellosaurus KTCTL-2 (CVCL_5871)

[Text version]
Cell line name KTCTL-2
Synonyms KTCTL2; KTCTL 2; RCC-EW
Accession CVCL_5871
Resource Identification Initiative To cite this cell line use: KTCTL-2 (RRID:CVCL_5871)
Comments Problematic cell line: Contaminated. KTCTL-2 and KTCTL-30 have been shown to be identical (CLS; on the basis of STR profile).
Misspelling: KTCL2; Cosmic=972922; PubMed=7915601.
Sequence variations
  • Mutation; HGNC; 12687; VHL; Simple; c.341-2A>T; ClinVar=VCV002034796; Zygosity=Unspecified; Note=Splice acceptor mutation (PubMed=7915601).
Disease Clear cell renal cell carcinoma (NCIt: C4033)
Clear cell renal carcinoma (ORDO: Orphanet_319276)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5878 ! KTCTL-30
Sex of cell Female
Age at sampling Age unspecified
Category Cancer cell line

PubMed=7915601; DOI=10.1038/ng0594-85
Gnarra J.R., Tory K., Weng Y., Schmidt L.S., Wei M.H., Li H., Latif F., Liu S., Chen F., Duh F.-M., Lubensky I.A., Duan D.R., Florence C., Pozzatti R., Walther M.M., Bander N.H., Grossman H.B., Brauch H., Pomer S., Brooks J.D., Isaacs W.B., Lerman M.I., Zbar B., Linehan W.M.
Mutations of the VHL tumour suppressor gene in renal carcinoma.
Nat. Genet. 7:85-90(1994)

PubMed=8086765; DOI=10.1007/BF00252823
Gross A.J., Wolff M., Fandrey J., Miersch W.-D., Dieckmann K.-P., Jelkmann W.
Prevalence of paraneoplastic erythropoietin production by renal cell carcinomas.
Clin. Investig. 72:337-340(1994)

PubMed=10190320; DOI=10.1007/s004320050252
Frank M.H., Pomer S.
Interferon alpha2b differentially affects proliferation of two human renal cell carcinoma cell lines differing in the P-glycoprotein-associated multidrug-resistant phenotype.
J. Cancer Res. Clin. Oncol. 125:117-120(1999)

PubMed=11720477; DOI=10.1054/bjoc.2001.2074
Stassar M.J.J.G., Devitt G., Brosius M., Rinnab L., Prang J., Schradin T., Simon J., Petersen S., Kopp-Schneider A., Zoller M.
Identification of human renal cell carcinoma associated genes by suppression subtractive hybridization.
Br. J. Cancer 85:1372-1382(2001)

Batrla R., Linnebacher M., Rudy W., Stumm S., Wallwiener D., Guckel B.
CD40-expressing carcinoma cells induce down-regulation of CD40 ligand (CD154) and impair T-cell functions.
Cancer Res. 62:2052-2057(2002)

PubMed=15977034; DOI=10.1007/s10334-005-0107-7
Lutz N.W., Franks S.E., Frank M.H., Pomer S., Hull W.E.
Investigation of multidrug resistance in cultured human renal cell carcinoma cells by 31P-NMR spectroscopy and treatment survival assays.
MAGMA 18:144-161(2005)

Cell line collections (Providers) CLS; 300246 - Discontinued
Cell line databases/resources cancercelllines; CVCL_5871
Encyclopedic resources Wikidata; Q54900639
Polymorphism and mutation databases Cosmic; 972922
Entry history
Entry creation04-Apr-2012
Last entry update05-Oct-2023
Version number22