ID   BJAB
AC   CVCL_5711
SY   BJAb; BJA-B; BJAB-1; BJA-B1; BJA-B-1
DR   BTO; BTO:0001931
DR   EFO; EFO_0002815
DR   AddexBio; C0003016/4884
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioGRID_ORCS_Cell_line; 741
DR   BioSample; SAMN03470800
DR   cancercelllines; CVCL_5711
DR   CGH-DB; 9192-4
DR   ChEMBL-Cells; CHEMBL3308492
DR   ChEMBL-Targets; CHEMBL613536
DR   CLS; 302006
DR   Cosmic; 998715
DR   Cosmic; 1019312
DR   Cosmic; 1037700
DR   Cosmic; 1086323
DR   Cosmic; 1127265
DR   Cosmic; 1517659
DR   Cosmic; 1588562
DR   Cosmic; 1945179
DR   DSMZ; ACC-757
DR   DSMZCellDive; ACC-757
DR   EGA; EGAS00001000610
DR   GEO; GSM33155
DR   GEO; GSM710427
DR   GEO; GSM710443
DR   GEO; GSM1059805
DR   GEO; GSM3150240
DR   IARC_TP53; 699
DR   Lonza; 107
DR   PharmacoDB; BJAB_102_2019
DR   PRIDE; PXD012087
DR   Progenetix; CVCL_5711
DR   PubChem_Cell_line; CVCL_5711
DR   TOKU-E; 3575
DR   Wikidata; Q50348210
RX   PubMed=62724;
RX   PubMed=171663;
RX   PubMed=175026;
RX   PubMed=179629;
RX   PubMed=1915267;
RX   PubMed=3495441;
RX   PubMed=3518877;
RX   PubMed=4369887;
RX   PubMed=6231253;
RX   PubMed=6286763;
RX   PubMed=6600440;
RX   PubMed=7316467;
RX   PubMed=8344493;
RX   PubMed=8515068;
RX   PubMed=8558920;
RX   PubMed=10739008;
RX   PubMed=11226526;
RX   PubMed=20054396;
RX   PubMed=23292937;
RX   PubMed=23257783;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=26589293;
RX   PubMed=26787899;
RX   PubMed=29416618;
RX   PubMed=29666304;
RX   PubMed=30165192;
RX   PubMed=31160637;
WW   https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/b/cell-lines-detail-73.html
CC   Part of: LL-100 blood cancer cell line panel.
CC   Population: African; Kenyan.
CC   Virology: EBV-negative. Even so that the original tumor tissue was infected with the B95-8 strain of EBV.
CC   Doubling time: ~22 hours (PubMed=179629); ~40-60 hours (DSMZ=ACC-757).
CC   HLA typing: A*01:01,02:01; B*13:02,35:01; C*04:01,06:02 (PubMed=26589293).
CC   HLA typing: A*01:02:83,02:01:01; B*13:02:01,35:01:01; C*04:01:01,06:02:01; DPB1*04:02:01G; DQA1*01:02:01,05:05:01; DQB1*03:01,06:04:01; DRB1*12:01:01,13:02:01 (CLS=302006).
CC   HLA typing: A*02:01:01,02:01:01; B*13:02:01,35:01:01; C*04:01:01,06:02:01; DPA1*01:03:01,01:03:01; DPB1*105:01,105:01; DQB1*03:01:01,06:09:01; DRA*01:01:01,01:02:02; DRB1*12:01:01,13:02:01 (DSMZCellDive=ACC-757).
CC   Microsatellite instability: Stable (MSS) (PubMed=10739008; PubMed=11226526).
CC   Sequence variation: Gene fusion; HGNC; 2092; CLTC + HGNC; 7132; KMT2A; Name(s)=KMT2A-CLTC (PubMed=31160637).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.His193Arg (c.578A>G); ClinVar=VCV000184979; Zygosity=Unspecified (PubMed=1915267; PubMed=8344493).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Omics: Array-based CGH.
CC   Omics: Deep exome analysis.
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Omics: Transcriptome analysis by RNAseq.
CC   Derived from site: In situ; Groin; UBERON=UBERON_0008337.
CC   Cell type: B-cell; CL=CL_0000236.
ST   Source(s): CLS=302006; DSMZ=ACC-757; Technion Genomics Center BCF; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 8,10
ST   D13S317: 9,11
ST   D16S539: 9,11 (DSMZ=ACC-757; Technion Genomics Center BCF; PubMed=25877200)
ST   D16S539: 9,12 (CLS=302006)
ST   D18S51: 16,21.2 (DSMZ=ACC-757)
ST   D18S51: 16,22 (Technion Genomics Center BCF; PubMed=25877200)
ST   D19S433: 12,14
ST   D21S11: 27,28
ST   D2S1338: 21
ST   D3S1358: 16
ST   D5S818: 12,13
ST   D7S820: 10,11
ST   D8S1179: 14,15 (CLS=302006; DSMZ=ACC-757; Technion Genomics Center BCF)
ST   D8S1179: 15 (PubMed=25877200)
ST   FGA: 27 (DSMZ=ACC-757)
ST   FGA: 27,28 (Technion Genomics Center BCF; PubMed=25877200)
ST   Penta D: 10,11
ST   Penta E: 7
ST   TH01: 7
ST   TPOX: 6,9
ST   vWA: 14,15 (CLS=302006; DSMZ=ACC-757; Technion Genomics Center BCF)
ST   vWA: 14,16 (PubMed=25877200)
DI   NCIt; C2912; Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   5Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 02-05-24; Version: 42
//
RX   PubMed=62724; DOI=10.1002/ijc.2910180513;
RA   Klein G., Zeuthen J., Terasaki P.I., Billing R.J., Honig R., Jondal M.,
RA   Westman A., Clements G.B.;
RT   "Inducibility of the Epstein-Barr virus (EBV) cycle and surface marker
RT   properties of EBV-negative lymphoma lines and their in vitro
RT   EBV-converted sublines.";
RL   Int. J. Cancer 18:639-652(1976).
//
RX   PubMed=171663; DOI=10.1073/pnas.72.9.3518;
RA   Steinitz M., Klein G.;
RT   "Comparison between growth characteristics of an Epstein-Barr virus
RT   (EBV)-genome-negative lymphoma line and its EBV-converted subline in
RT   vitro.";
RL   Proc. Natl. Acad. Sci. U.S.A. 72:3518-3520(1975).
//
RX   PubMed=175026; DOI=10.1002/ijc.2910170203;
RA   Fresen K.-O., zur Hausen H.;
RT   "Establishment of EBNA-expressing cell lines by infection of
RT   Epstein-Barr virus (EBV)-genome-negative human lymphoma cells with
RT   different EBV strains.";
RL   Int. J. Cancer 17:161-166(1976).
//
RX   PubMed=179629;
RA   Menezes J., Leibold W., Klein G., Clements G.B.;
RT   "Establishment and characterization of an Epstein-Barr virus
RT   (EBV)-negative lymphoblastoid B cell line (BJA-B) from an exceptional,
RT   EBV-genome-negative African Burkitt's lymphoma.";
RL   Biomedicine 22:276-284(1975).
//
RX   PubMed=1915267; DOI=10.1002/j.1460-2075.1991.tb07837.x;
RA   Farrell P.J., Allan G.J., Shanahan F., Vousden K.H., Crook T.;
RT   "p53 is frequently mutated in Burkitt's lymphoma cell lines.";
RL   EMBO J. 10:2879-2887(1991).
//
RX   PubMed=3495441; DOI=10.1002/eji.1830170503;
RA   Kanowith-Klein S., Saxon A., Uittenbogaart C.H.;
RT   "Constitutive production of B cell differentiation factor-like
RT   activity by human T and B cell lines.";
RL   Eur. J. Immunol. 17:593-598(1987).
//
RX   PubMed=3518877; DOI=10.3109/07357908609038260;
RA   Fogh J.;
RT   "Human tumor lines for cancer research.";
RL   Cancer Invest. 4:157-184(1986).
//
RX   PubMed=4369887; DOI=10.1073/pnas.71.8.3283;
RA   Klein G., Lindahl T.L., Jondal M., Leibold W., Menezes J., Nilsson K.,
RA   Sundstrom C.;
RT   "Continuous lymphoid cell lines with characteristics of B cells
RT   (bone-marrow-derived), lacking the Epstein-Barr virus genome and
RT   derived from three human lymphomas.";
RL   Proc. Natl. Acad. Sci. U.S.A. 71:3283-3286(1974).
//
RX   PubMed=6231253; DOI=10.1002/ijc.2910330407;
RA   Ehlin-Henriksson B., Klein G.;
RT   "Distinction between Burkitt lymphoma subgroups by monoclonal
RT   antibodies: relationships between antigen expression and type of
RT   chromosomal translocation.";
RL   Int. J. Cancer 33:459-463(1984).
//
RX   PubMed=6286763; DOI=10.4049/jimmunol.129.3.1336;
RA   Benjamin D., Magrath I.T., Maguire R.T., Janus C., Todd H.D.,
RA   Parsons R.G.;
RT   "Immunoglobulin secretion by cell lines derived from African and
RT   American undifferentiated lymphomas of Burkitt's and non-Burkitt's
RT   type.";
RL   J. Immunol. 129:1336-1342(1982).
//
RX   PubMed=6600440; DOI=10.1007/BF02617996;
RA   Uittenbogaart C.H., Cantor Y., Fahey J.L.;
RT   "Growth of human malignant lymphoid cell lines in serum-free medium.";
RL   In Vitro 19:67-72(1983).
//
RX   PubMed=7316467; DOI=10.1111/j.1469-1809.1980.tb00953.x;
RA   Povey S., Jeremiah S., Arthur E., Steel M., Klein G.;
RT   "Differences in genetic stability between human cell lines from
RT   patients with and without lymphoreticular malignancy.";
RL   Ann. Hum. Genet. 44:119-133(1980).
//
RX   PubMed=8344493; DOI=10.1096/fasebj.7.10.8344493;
RA   Bhatia K.G., Goldschmidts W., Gutierrez M.I., Gaidano G., Dalla-Favera R.,
RA   Magrath I.T.;
RT   "Hemi- or homozygosity: a requirement for some but not other p53
RT   mutant proteins to accumulate and exert a pathogenetic effect.";
RL   FASEB J. 7:951-956(1993).
//
RX   PubMed=8515068; DOI=10.4049/jimmunol.150.12.5418;
RA   Jain V.K., Judde J.-G., Max E.E., Magrath I.T.;
RT   "Variable IgH chain enhancer activity in Burkitt's lymphomas suggests
RT   an additional, direct mechanism of c-myc deregulation.";
RL   J. Immunol. 150:5418-5428(1993).
//
RX   PubMed=8558920;
RA   Dirks W.G., Zaborski M., Jager K., Challier C., Shiota M.,
RA   Quentmeier H., Drexler H.G.;
RT   "The (2;5)(p23;q35) translocation in cell lines derived from malignant
RT   lymphomas: absence of t(2;5) in Hodgkin-analogous cell lines.";
RL   Leukemia 10:142-149(1996).
//
RX   PubMed=10739008; DOI=10.1016/S0145-2126(99)00182-4;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Frequent microsatellite instability and BAX mutations in T cell acute
RT   lymphoblastic leukemia cell lines.";
RL   Leuk. Res. 24:255-262(2000).
//
RX   PubMed=11226526; DOI=10.1016/S0145-2126(00)00121-1;
RA   Inoue K., Kohno T., Takakura S., Hayashi Y., Mizoguchi H., Yokota J.;
RT   "Corrigendum to: Frequent microsatellite instability and BAX mutations
RT   in T cell acute lymphoblastic leukemia cell lines Leukemia Research 24
RT   (2000),255-262.";
RL   Leuk. Res. 25:275-278(2001).
//
RX   PubMed=20054396; DOI=10.1038/nature08638;
RA   Davis R.E., Ngo V.N., Lenz G., Tolar P., Young R.M., Romesser P.B.,
RA   Kohlhammer H., Lamy L., Zhao H., Yang Y.-D., Xu W.-H., Shaffer A.L. III,
RA   Wright G., Xiao W.-M., Powell J.I., Jiang J.-K., Thomas C.J., Rosenwald A.,
RA   Ott G., Muller-Hermelink H.-K., Gascoyne R.D., Connors J.M.,
RA   Johnson N.A., Rimsza L.M., Campo E., Jaffe E.S., Wilson W.H.,
RA   Delabie J., Smeland E.B., Fisher R.I., Braziel R.M., Tubbs R.R.,
RA   Cook J.R., Weisenburger D.D., Chan W.C., Pierce S.K., Staudt L.M.;
RT   "Chronic active B-cell-receptor signalling in diffuse large B-cell
RT   lymphoma.";
RL   Nature 463:88-92(2010).
//
RX   PubMed=23292937; DOI=10.1073/pnas.1205299110;
RA   Zhang J., Grubor V., Love C.L., Banerjee A., Richards K.L.,
RA   Mieczkowski P.A., Dunphy C., Choi W., Au W.Y., Srivastava G.,
RA   Lugar P.L., Rizzieri D.A., Lagoo A.S., Bernal-Mizrachi L., Mann K.P.,
RA   Flowers C.R., Naresh K., Evens A.M., Gordon L.I., Czader M.B., Gill J.I.,
RA   Hsi E.D., Liu Q.-Q., Fan A., Walsh K., Jima D., Smith L.L., Johnson A.J.,
RA   Byrd J.C., Luftig M.A., Ni T., Zhu J., Chadburn A., Levy S.,
RA   Dunson D.B., Dave S.S.;
RT   "Genetic heterogeneity of diffuse large B-cell lymphoma.";
RL   Proc. Natl. Acad. Sci. U.S.A. 110:1398-1403(2013).
//
RX   PubMed=23257783; DOI=10.1038/leu.2012.367;
RA   Wenzel S.-S., Grau M., Mavis C., Hailfinger S., Wolf A., Madle H.,
RA   Deeb G., Dorken B., Thome M., Lenz P., Dirnhofer S.,
RA   Hernandez-Ilizaliturri F.J., Tzankov A., Lenz G.;
RT   "MCL1 is deregulated in subgroups of diffuse large B-cell lymphoma.";
RL   Leukemia 27:1381-1390(2013).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn C., Durinck S., Stawiski E.W., Haverty P.M., Jiang Z.-S.,
RA   Liu H.-B., Degenhardt J., Mayba O., Gnad F., Liu J.-F., Pau G.,
RA   Reeder J., Cao Y., Mukhyala K., Selvaraj S.K., Yu M.-M., Zynda G.J.,
RA   Brauer M.J., Wu T.D., Gentleman R.C., Manning G., Yauch R.L.,
RA   Bourgon R., Stokoe D., Modrusan Z., Neve R.M., de Sauvage F.J.,
RA   Settleman J., Seshagiri S., Zhang Z.-M.;
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu M., Selvaraj S.K., Liang-Chu M.M.Y., Aghajani S., Busse M.,
RA   Yuan J., Lee G., Peale F.V., Klijn C., Bourgon R., Kaminker J.S.,
RA   Neve R.M.;
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5;
RA   Scholtalbers J., Boegel S., Bukur T., Byl M., Goerges S., Sorn P.,
RA   Loewer M., Sahin U., Castle J.C.;
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=26787899; DOI=10.1073/pnas.1524677113;
RA   Dekker J.D., Park D., Shaffer A.L. III, Kohlhammer H., Deng W.,
RA   Lee B.-K., Ippolito G.C., Georgiou G., Iyer V.R., Staudt L.M.,
RA   Tucker H.O.;
RT   "Subtype-specific addiction of the activated B-cell subset of diffuse
RT   large B-cell lymphoma to FOXP1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 113:E577-E586(2016).
//
RX   PubMed=29416618; DOI=10.18632/oncotarget.20378;
RA   Liu W., Chen J., Tamayo A.T., Ruan C.-G., Li L., Zhou S.-H., Shen C.,
RA   Young K.H., Westin J., Davis R.E., Hu S.-M., Medeiros L.J., Ford R.J. Jr.,
RA   Pham L.V.;
RT   "Preclinical efficacy and biological effects of the oral proteasome
RT   inhibitor ixazomib in diffuse large B-cell lymphoma.";
RL   Oncotarget 9:346-360(2018).
//
RX   PubMed=29666304; DOI=10.1158/1078-0432.CCR-17-3004;
RA   Pham L.V., Huang S.-J., Zhang H., Zhang J., Bell T., Zhou S.-H.,
RA   Pogue E., Ding Z.-Y., Lam L., Westin J., Davis R.E., Young K.H.,
RA   Medeiros L.J., Ford R.J. Jr., Nomie K., Zhang L., Wang M.;
RT   "Strategic therapeutic targeting to overcome venetoclax resistance in
RT   aggressive B-cell lymphomas.";
RL   Clin. Cancer Res. 24:3967-3980(2018).
//
RX   PubMed=30165192; DOI=10.1016/j.canlet.2018.08.020;
RA   Qu C.-J., Kunkalla K., Vaghefi A., Frederiksen J.K., Liu Y.-D.,
RA   Chapman J.R., Blonska M., Bernal-Mizrachi L., Alderuccio J.P.,
RA   Lossos I.S., Landgraf R., Vega-Vazquez F.;
RT   "Smoothened stabilizes and protects TRAF6 from degradation: a novel
RT   non-canonical role of smoothened with implications in lymphoma
RT   biology.";
RL   Cancer Lett. 436:149-158(2018).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x;
RA   Quentmeier H., Pommerenke C., Dirks W.G., Eberth S., Koeppel M.,
RA   MacLeod R.A.F., Nagel S., Steube K., Uphoff C.C., Drexler H.G.;
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218-8218(2019).
//