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Cellosaurus NALM-27 (CVCL_5665)

[Text version]
Cell line name NALM-27
Synonyms NALM27; Nalm27
Accession CVCL_5665
Resource Identification Initiative To cite this cell line use: NALM-27 (RRID:CVCL_5665)
Comments Population: Japanese.
Doubling time: 4-5 days (PubMed=9710720).
Omics: Array-based CGH.
Omics: Deep exome analysis.
Omics: Transcriptome analysis by RNAseq.
Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
Sequence variations
Disease Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2) BCR-ABL1 (NCIt: C82192)
Mixed phenotype acute leukemia with t(9;22)(q34.1;q11.2) (ORDO: Orphanet_589534)
Species of origin Homo sapiens (Human) (NCBI Taxonomy: 9606)
Originate from same individual CVCL_5666 ! NALM-28
CVCL_5668 ! NALM-30
CVCL_5669 ! NALM-31
CVCL_5670 ! NALM-32
Sex of cell Male
Age at sampling 38Y
Category Cancer cell line
STR profile Source(s): JCRB=JCRB1830

Markers:
AmelogeninX,Y
CSF1PO7,12
D5S81811,13
D7S8208,11
D13S3178
D16S5399
TH016,7
TPOX8
vWA17,18

Run an STR similarity search on this cell line
Publications

PubMed=9067587; DOI=10.1038/sj.leu.2400571
Uphoff C.C., MacLeod R.A.F., Denkmann S.A., Golub T.R., Borkhardt A., Janssen J.W.G., Drexler H.G.
Occurrence of TEL-AML1 fusion resulting from (12;21) translocation in human early B-lineage leukemia cell lines.
Leukemia 11:441-447(1997)

PubMed=9680106; DOI=10.1016/S0145-2126(98)00050-2
Matsuo Y., Drexler H.G.
Establishment and characterization of human B cell precursor-leukemia cell lines.
Leuk. Res. 22:567-579(1998)

PubMed=9710720
Ariyasu T., Matsuo Y., Harashima A., Nakamura S., Takaba S., Tsubota T., Orita K.
Establishment and characterization of 'biphenotypic' acute leukemia cell lines with a variant Ph translocation t(9;22;10) (q34;q11;q22).
Hum. Cell 11:43-50(1998)

PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4
Drexler H.G., MacLeod R.A.F., Uphoff C.C.
Leukemia cell lines: in vitro models for the study of Philadelphia chromosome-positive leukemia.
Leuk. Res. 23:207-215(1999)

PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9
Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.
ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.
Leuk. Res. 23:1055-1060(1999)

PubMed=10637496; DOI=10.1038/sj.leu.2401604
Drexler H.G., Fombonne S., Matsuo Y., Hu Z.-B., Hamaguchi H., Uphoff C.C.
p53 alterations in human leukemia-lymphoma cell lines: in vitro artifact or prerequisite for cell immortalization?
Leukemia 14:198-206(2000)

DOI=10.1016/B978-0-12-221970-2.50457-5
Drexler H.G.
The leukemia-lymphoma cell line factsbook.
(In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001)

PubMed=29786757; DOI=10.1007/s12185-018-2474-7
Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H., Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T., Sugita K., Hosoi H.
Copy number abnormality of acute lymphoblastic leukemia cell lines based on their genetic subtypes.
Int. J. Hematol. 108:312-318(2018)

PubMed=34940123; DOI=10.3390/cimb43030149; PMCID=PMC8929001
Quentmeier H., Pommerenke C., Drexler H.G.
Molecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression.
Curr. Issues Mol. Biol. 43:2147-2156(2021)

PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068
Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C., Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H., Minegishi M., Iwamoto S., Sugita K., Inukai T.
Glucocorticoid receptor gene mutations confer glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.
J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022)

Cross-references
Cell line collections (Providers) JCRB; JCRB1830
Encyclopedic resources Wikidata; Q54907409
Gene expression databases ArrayExpress; E-MTAB-11038
ArrayExpress; E-MTAB-11039
Polymorphism and mutation databases Cosmic; 999736
Cosmic; 1130247
Cosmic; 2491084
Entry history
Entry creation04-Apr-2012
Last entry update19-Dec-2024
Version number20