ID   ZR-75-B
AC   CVCL_5614
SY   ZR75-B; ZR-75B; ZR-75b; ZR75B
DR   CLO; CLO_0009924
DR   EFO; EFO_0001264
DR   ArrayExpress; E-TABM-157
DR   ArrayExpress; E-TABM-244
DR   cancercelllines; CVCL_5614
DR   Cosmic; 1136345
DR   Cosmic; 1176641
DR   DepMap; ACH-002331
DR   GEO; GSM1053730
DR   GEO; GSM1172910
DR   GEO; GSM1173006
DR   GEO; GSM1215271
DR   LINCS_HMS; 51096
DR   LINCS_LDP; LCL-2077
DR   PharmacoDB; ZR75B_1691_2019
DR   Wikidata; Q54996122
RX   PubMed=6178756;
RX   PubMed=8562478;
RX   PubMed=9815641;
RX   PubMed=17157791;
RX   PubMed=18516279;
RX   PubMed=24094812;
RX   PubMed=24162158;
RX   PubMed=24176112;
RX   PubMed=25960936;
WW   Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: JWGray breast cancer cell line panel.
CC   Population: Caucasian.
CC   Doubling time: 30.5 hours (PubMed=8562478; PubMed=9815641); 44.80 hours (JWGray panel).
CC   HLA typing: B*35:01,35:01; C*04:01,04:01; DQB1*05:01,05:01 (PubMed=25960936).
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Glu162Lys (c.484G>A); ClinVar=VCV001034833; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Leu108Arg (c.323T>G); Zygosity=Homozygous (from parent cell line).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; SNP array analysis.
CC   Misspelling: ZRB75; Note=Occasionally.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0588 ! ZR-75-1
SX   Female
AG   63Y
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 31
CH   CVCL_ZZ26 ! ZR75B Ad120
CH   CVCL_ZZ27 ! ZR75B Ad24
CH   CVCL_ZZ28 ! ZR75B Tx10
CH   CVCL_ZZ29 ! ZR75B Tx40
CH   CVCL_ZZ30 ! ZR75B Vb10
//
RX   PubMed=8562478;
RA   Wosikowski, Katja
RA   Regis, Joanna T.
RA   Robey, Robert W.
RA   Alvarez, Manuel
RA   Buters, Jeroen Titus Maria
RA   Gudas, Jean Marie
RA   Bates, Susan E.
RT   "Normal p53 status and function despite the development of drug
RT   resistance in human breast cancer cells.";
RL   Cell Growth Differ. 6:1395-1403(1995).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776;
RA   Prat, Aleix
RA   Karginova, Olga
RA   Parker, Joel S.
RA   Fan, Cheng
RA   He, Xia-Ping
RA   Bixby, Lisa M.
RA   Harrell, J. Chuck
RA   Roman, Erick
RA   Adamo, Barbara
RA   Troester, Melissa A.
RA   Perou, Charles M.
RT   "Characterization of cell lines derived from breast cancers and normal
RT   mammary tissues for the study of the intrinsic molecular subtypes.";
RL   Breast Cancer Res. Treat. 142:237-255(2013).
//
RX   PubMed=6178756; DOI=10.1172/JCI110624; PMCID=PMC371243;
RA   Jolivet, Jacques
RA   Schilsky, Richard L.
RA   Bailey, Brenda D.
RA   Drake, James C.
RA   Chabner, Bruce Allan
RT   "Synthesis, retention, and biological activity of methotrexate
RT   polyglutamates in cultured human breast cancer cells.";
RL   J. Clin. Invest. 70:351-360(1982).
//
RX   PubMed=24094812; DOI=10.1016/j.ccr.2013.08.020; PMCID=PMC3931310;
RA   Timmerman, Luika A.
RA   Holton, Thomas
RA   Yuneva, Mariia
RA   Louie, Raymond J.
RA   Padro, Merce
RA   Daemen, Anneleen
RA   Hu, Min
RA   Chan, Denise A.
RA   Ethier, Stephen P.
RA   van 't Veer, Laura J.
RA   Polyak, Kornelia
RA   McCormick, Frank
RA   Gray, Joe W.
RT   "Glutamine sensitivity analysis identifies the xCT antiporter as a
RT   common triple-negative breast tumor therapeutic target.";
RL   Cancer Cell 24:450-465(2013).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=18516279; DOI=10.1016/j.molonc.2007.02.004; PMCID=PMC2391005;
RA   Kenny, Paraic A.
RA   Lee, Genee Y.
RA   Myers, Connie A.
RA   Neve, Richard M.
RA   Semeiks, Jeremy R.
RA   Spellman, Paul T.
RA   Lorenz, Kristina
RA   Lee, Eva H.
RA   Barcellos-Hoff, Mary Helen
RA   Petersen, Ole William
RA   Gray, Joe W.
RA   Bissell, Mina J.
RT   "The morphologies of breast cancer cell lines in three-dimensional
RT   assays correlate with their profiles of gene expression.";
RL   Mol. Oncol. 1:84-96(2007).
//
RX   PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521;
RA   Neve, Richard M.
RA   Chin, Koei
RA   Fridlyand, Jane
RA   Yeh, Jennifer
RA   Baehner, Frederick L.
RA   Fevr, Tea
RA   Clark, Laura
RA   Bayani, Nora
RA   Coppe, Jean-Philippe
RA   Tong, Frances
RA   Speed, Terry
RA   Spellman, Paul T.
RA   DeVries, Sandy
RA   Lapuk, Anna
RA   Wang, Nick J.
RA   Kuo, Wen-Lin
RA   Stilwell, Jackie L.
RA   Pinkel, Daniel
RA   Albertson, Donna G.
RA   Waldman, Frederic M.
RA   McCormick, Frank
RA   Dickson, Robert Brent
RA   Johnson, Michael D.
RA   Lippman, Marc E.
RA   Ethier, Stephen P.
RA   Gazdar, Adi F.
RA   Gray, Joe W.
RT   "A collection of breast cancer cell lines for the study of
RT   functionally distinct cancer subtypes.";
RL   Cancer Cell 10:515-527(2006).
//
RX   PubMed=9815641;
RA   Wosikowski, Katja
RA   Schuurhuis, Danita H.
RA   Kops, Geert J.P.L.
RA   Saceda, Miguel
RA   Bates, Susan E.
RT   "Altered gene expression in drug-resistant human breast cancer
RT   cells.";
RL   Clin. Cancer Res. 3:2405-2414(1997).
//