ID   SUM1315MO2
AC   CVCL_5589
SY   SUM1315M02; SUM1315-MO2; SUM-1315M02; SUM 1315M02; SUM-1315; SUM 1315; SUM1315; 1315M02
DR   BTO; BTO_0005933
DR   CLO; CLO_0009916
DR   EFO; EFO_0001239
DR   ArrayExpress; E-MTAB-2706
DR   ArrayExpress; E-TABM-157
DR   BioSample; SAMN03471829
DR   cancercelllines; CVCL_5589
DR   Cell_Model_Passport; SIDM01836
DR   Cosmic; 904394
DR   Cosmic; 997924
DR   Cosmic; 1046961
DR   Cosmic; 1287925
DR   Cosmic; 1289417
DR   Cosmic; 1460228
DR   DepMap; ACH-001389
DR   EGA; EGAS00001000610
DR   GEO; GSM217599
DR   GEO; GSM421893
DR   GEO; GSM1008915
DR   GEO; GSM1053733
DR   GEO; GSM1172896
DR   GEO; GSM1172991
DR   GEO; GSM1214566
DR   GEO; GSM1374910
DR   IARC_TP53; 24341
DR   LINCS_HMS; 51081
DR   LINCS_LDP; LCL-2066
DR   PharmacoDB; SUM1315M02_1508_2019
DR   Progenetix; CVCL_5589
DR   SLKBase; 1106
DR   Wikidata; Q54970827
RX   PubMed=10424408;
RX   PubMed=10604729;
RX   PubMed=10969801;
RX   PubMed=15677628;
RX   PubMed=16397213;
RX   PubMed=16541312;
RX   PubMed=17157791;
RX   PubMed=19593635;
RX   PubMed=21778573;
RX   PubMed=22032724;
RX   PubMed=23151021;
RX   PubMed=23401782;
RX   PubMed=23601657;
RX   PubMed=24162158;
RX   PubMed=24176112;
RX   PubMed=25485619;
RX   PubMed=25877200;
RX   PubMed=25960936;
RX   PubMed=26589293;
RX   PubMed=32715085;
WW   Info; Synapse; JWGray panel; https://www.synapse.org/#!Synapse:syn2346643/wiki/62255
WW   Provider; BioIVT/Asterand; -; https://bioivt.com/sum-breast-cancer-cell-lines/
CC   Group: Triple negative breast cancer (TNBC) cell line.
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Part of: JWGray breast cancer cell line panel.
CC   Part of: KuDOS 95 cell line panel.
CC   Characteristics: Established from tumor tissue after two passages in nude mice.
CC   Characteristics: EGF dependent.
CC   Doubling time: 94.59 hours (JWGray panel).
CC   HLA typing: A*31:01,32:01; B*39:01,40:01; C*03:04,12:03; DQA1*01:02,05:02; DQB1*03:02,06:04; DRB1*15:01,04 (PubMed=25960936).
CC   HLA typing: A*31:01,32:01; B*39:01,40:01; C*03:04,12:03 (PubMed=26589293).
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Homozygous (PubMed=19593635).
CC   Sequence variation: Mutation; HGNC; HGNC:1100; BRCA1; Simple; p.Glu23Valfs*17 (c.68_69delAG) (c.66_67AG[1]) (185delAG); ClinVar=VCV000017662; Zygosity=Hemizygous (PubMed=16397213; PubMed=19593635; PubMed=22032724).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys135Phe (c.404G>T); ClinVar=VCV000376559; Zygosity=Unspecified (PubMed=16541312).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Proteomics; Expression; Reverse-phase protein array.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Transcriptomics; miRNA profiling; Microarray.
CC   Omics: Transcriptomics; RNAseq.
CC   Omics: Variations; Array-based CGH.
CC   Omics: Variations; SNP array analysis.
CC   Derived from site: Metastatic; Skin; UBERON=UBERON_0002097.
ST   Source(s): DepMap=ACH-001389; PubMed=25877200
ST   Amelogenin: X
ST   CSF1PO: 12
ST   D13S317: 11,12
ST   D16S539: 11
ST   D18S51: 12
ST   D21S11: 28,29
ST   D3S1358: 18
ST   D5S818: 13
ST   D7S820: 8,12
ST   D8S1179: 13,15
ST   FGA: 25
ST   Penta D: 13,15
ST   Penta E: 5
ST   TH01: 9.3
ST   TPOX: 8,10
ST   vWA: 17
DI   NCIt; C4194; Invasive breast carcinoma of no special type
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 10-04-25; Version: 36
//
RX   PubMed=24162158; DOI=10.1007/s10549-013-2743-3; PMCID=PMC3832776;
RA   Prat, Aleix
RA   Karginova, Olga
RA   Parker, Joel S.
RA   Fan, Cheng
RA   He, Xia-Ping
RA   Bixby, Lisa M.
RA   Harrell, J. Chuck
RA   Roman, Erick
RA   Adamo, Barbara
RA   Troester, Melissa A.
RA   Perou, Charles M.
RT   "Characterization of cell lines derived from breast cancers and normal
RT   mammary tissues for the study of the intrinsic molecular subtypes.";
RL   Breast Cancer Res. Treat. 142:237-255(2013).
//
RX   PubMed=24176112; DOI=10.1186/gb-2013-14-10-r110; PMCID=PMC3937590;
RA   Daemen, Anneleen
RA   Griffith, Obi L.
RA   Heiser, Laura M.
RA   Wang, Nicholas J.
RA   Enache, Oana M.
RA   Sanborn, Zachary J.
RA   Pepin, Francois
RA   Durinck, Steffen
RA   Korkola, James E.
RA   Griffith, Malachi
RA   Hur, Joe S.
RA   Huh, Nam
RA   Chung, Jongsuk
RA   Cope, Leslie
RA   Fackler, Mary Jo
RA   Umbricht, Christopher Benedict
RA   Sukumar, Saraswati
RA   Seth, Pankaj
RA   Sukhatme, Vikas P.
RA   Jakkula, Lakshmi R.
RA   Lu, Yi-Ling
RA   Mills, Gordon B.
RA   Cho, Raymond J.
RA   Collisson, Eric A.
RA   van 't Veer, Laura J.
RA   Spellman, Paul T.
RA   Gray, Joe W.
RT   "Modeling precision treatment of breast cancer.";
RL   Genome Biol. 14:R110.1-R110.14(2013).
//
RX   PubMed=26589293; DOI=10.1186/s13073-015-0240-5; PMCID=PMC4653878;
RA   Scholtalbers, Jelle
RA   Boegel, Sebastian
RA   Bukur, Thomas
RA   Byl, Marius
RA   Goerges, Sebastian
RA   Sorn, Patrick
RA   Loewer, Martin
RA   Sahin, Ugur
RA   Castle, John C.
RT   "TCLP: an online cancer cell line catalogue integrating HLA type,
RT   predicted neo-epitopes, virus and gene expression.";
RL   Genome Med. 7:118.1-118.7(2015).
//
RX   PubMed=23151021; DOI=10.1186/1471-2164-13-619; PMCID=PMC3546428;
RA   Grigoriadis, Anita
RA   Mackay, Alan
RA   Noel, Elodie
RA   Wu, Pei-Jun
RA   Natrajan, Rachael
RA   Frankum, Jessica
RA   Reis-Filho, Jorge Sergio
RA   Tutt, Andrew N.J.
RT   "Molecular characterisation of cell line models for triple-negative
RT   breast cancers.";
RL   BMC Genomics 13:619.1-619.14(2012).
//
RX   PubMed=25877200; DOI=10.1038/nature14397;
RA   Yu, Ma-Mie
RA   Selvaraj, Suresh K.
RA   Liang-Chu, May M.Y.
RA   Aghajani, Sahar
RA   Busse, Matthew
RA   Yuan, Jean
RA   Lee, Genee
RA   Peale, Franklin V.
RA   Klijn, Christiaan
RA   Bourgon, Richard
RA   Kaminker, Joshua S.
RA   Neve, Richard M.
RT   "A resource for cell line authentication, annotation and quality
RT   control.";
RL   Nature 520:307-311(2015).
//
RX   PubMed=21778573; DOI=10.3233/BD-2010-0307; PMCID=PMC3532890;
RA   Chavez, Kathryn J.
RA   Garimella, Sireesha Venkata
RA   Lipkowitz, Stanley
RT   "Triple negative breast cancer cell lines: one tool in the search for
RT   better treatment of triple negative breast cancer.";
RL   Breast Dis. 32:35-48(2010).
//
RX   PubMed=23401782; DOI=10.1155/2013/872743; PMCID=PMC3562669;
RA   Barnabas, Nandita
RA   Cohen, Dalia
RT   "Phenotypic and molecular characterization of MCF10DCIS and SUM breast
RT   cancer cell lines.";
RL   Int. J. Breast Cancer 2013:872743.1-872743.16(2013).
//
RX   PubMed=10604729; DOI=10.1038/sj.bjc.6695007; PMCID=PMC2362964;
RA   Forozan, Farahnaz
RA   Veldman, Robin
RA   Ammerman, Cheryl A.
RA   Parsa, Nasser Z.
RA   Kallioniemi, Anne H.
RA   Kallioniemi, Olli-Pekka
RA   Ethier, Stephen P.
RT   "Molecular cytogenetic analysis of 11 new breast cancer cell lines.";
RL   Br. J. Cancer 81:1328-1334(1999).
//
RX   PubMed=25485619; DOI=10.1038/nbt.3080;
RA   Klijn, Christiaan
RA   Durinck, Steffen
RA   Stawiski, Eric W.
RA   Haverty, Peter M.
RA   Jiang, Zhao-Shi
RA   Liu, Han-Bin
RA   Degenhardt, Jeremiah
RA   Mayba, Oleg
RA   Gnad, Florian
RA   Liu, Jin-Feng
RA   Pau, Gregoire
RA   Reeder, Jens
RA   Cao, Yi
RA   Mukhyala, Kiran
RA   Selvaraj, Suresh K.
RA   Yu, Ma-Mie
RA   Zynda, Gregory J.
RA   Brauer, Matthew J.
RA   Wu, Thomas D.
RA   Gentleman, Robert Clifford
RA   Manning, Gerard
RA   Yauch, Robert L.
RA   Bourgon, Richard
RA   Stokoe, David
RA   Modrusan, Zora
RA   Neve, Richard M.
RA   de Sauvage, Frederic J.
RA   Settleman, Jeffrey
RA   Seshagiri, Somasekar
RA   Zhang, Ze-Min
RT   "A comprehensive transcriptional portrait of human cancer cell
RT   lines.";
RL   Nat. Biotechnol. 33:306-312(2015).
//
RX   PubMed=17157791; DOI=10.1016/j.ccr.2006.10.008; PMCID=PMC2730521;
RA   Neve, Richard M.
RA   Chin, Koei
RA   Fridlyand, Jane
RA   Yeh, Jennifer
RA   Baehner, Frederick L.
RA   Fevr, Tea
RA   Clark, Laura
RA   Bayani, Nora
RA   Coppe, Jean-Philippe
RA   Tong, Frances
RA   Speed, Terry
RA   Spellman, Paul T.
RA   DeVries, Sandy
RA   Lapuk, Anna
RA   Wang, Nick J.
RA   Kuo, Wen-Lin
RA   Stilwell, Jackie L.
RA   Pinkel, Daniel
RA   Albertson, Donna G.
RA   Waldman, Frederic M.
RA   McCormick, Frank
RA   Dickson, Robert Brent
RA   Johnson, Michael D.
RA   Lippman, Marc E.
RA   Ethier, Stephen P.
RA   Gazdar, Adi F.
RA   Gray, Joe W.
RT   "A collection of breast cancer cell lines for the study of
RT   functionally distinct cancer subtypes.";
RL   Cancer Cell 10:515-527(2006).
//
RX   PubMed=15677628; DOI=10.1093/carcin/bgi032;
RA   Gorringe, Kylie Louise
RA   Chin, Suet-Feung
RA   Pharoah, Paul D.P.
RA   Staines, Joanne M.
RA   Oliveira, Carla
RA   Edwards, Paul A.W.
RA   Caldas, Carlos
RT   "Evidence that both genetic instability and selection contribute to
RT   the accumulation of chromosome alterations in cancer.";
RL   Carcinogenesis 26:923-930(2005).
//
RX   PubMed=23601657; DOI=10.1186/bcr3415; PMCID=PMC3672661;
RA   Riaz, Muhammad
RA   van Jaarsveld, Marijn T.M.
RA   Hollestelle, Antoinette
RA   Prager-van der Smissen, Wendy J.C.
RA   Heine, Anouk A.J.
RA   Boersma, Antonius W.M.
RA   Liu, Jing-Jing
RA   Helmijr, Jean C.A.
RA   Ozturk, Bahar
RA   Smid, Marcel
RA   Wiemer, Erik A.C.
RA   Foekens, John A.
RA   Martens, John W.M.
RT   "miRNA expression profiling of 51 human breast cancer cell lines
RT   reveals subtype and driver mutation-specific miRNAs.";
RL   Breast Cancer Res. 15:R33.1-R33.17(2013).
//
RX   PubMed=22032724; DOI=10.1186/1755-8794-4-75; PMCID=PMC3227591;
RA   Ha, Kevin C.H.
RA   Lalonde, Emilie
RA   Li, Li-Li
RA   Cavallone, Luca
RA   Natrajan, Rachael
RA   Lambros, Maryou B.
RA   Mitsopoulos, Costas
RA   Hakas, Jarle
RA   Kozarewa, Iwanka
RA   Fenwick, Kerry
RA   Lord, Christopher J.
RA   Ashworth, Alan
RA   Vincent-Salomon, Anne
RA   Basik, Mark
RA   Reis-Filho, Jorge Sergio
RA   Majewski, Jacek
RA   Foulkes, William David
RT   "Identification of gene fusion transcripts by transcriptome sequencing
RT   in BRCA1-mutated breast cancers and cell lines.";
RL   BMC Med. Genomics 4:75.1-75.13(2011).
//
RX   PubMed=10969801;
RA   Forozan, Farahnaz
RA   Mahlamaki, Eija H.
RA   Monni, Outi
RA   Chen, Yi-Dong
RA   Veldman, Robin
RA   Jiang, Yuan
RA   Gooden, Gerald C.
RA   Ethier, Stephen P.
RA   Kallioniemi, Anne H.
RA   Kallioniemi, Olli-Pekka
RT   "Comparative genomic hybridization analysis of 38 breast cancer cell
RT   lines: a basis for interpreting complementary DNA microarray data.";
RL   Cancer Res. 60:4519-4525(2000).
//
RX   PubMed=10424408; DOI=10.1023/A:1006135331912;
RA   Woods Ignatoski, Kathleen M.
RA   Ethier, Stephen P.
RT   "Constitutive activation of pp125fak in newly isolated human breast
RT   cancer cell lines.";
RL   Breast Cancer Res. Treat. 54:173-182(1999).
//
RX   PubMed=16541312; DOI=10.1007/s10549-006-9186-z;
RA   Wasielewski, Marijke
RA   Elstrodt, Fons
RA   Klijn, Jan G.M.
RA   Berns, Els M.J.J.
RA   Schutte, Mieke
RT   "Thirteen new p53 gene mutants identified among 41 human breast cancer
RT   cell lines.";
RL   Breast Cancer Res. Treat. 99:97-101(2006).
//
RX   PubMed=25960936; DOI=10.4161/21624011.2014.954893; PMCID=PMC4355981;
RA   Boegel, Sebastian
RA   Lower, Martin
RA   Bukur, Thomas
RA   Sahin, Ugur
RA   Castle, John C.
RT   "A catalog of HLA type, HLA expression, and neo-epitope candidates in
RT   human cancer cell lines.";
RL   OncoImmunology 3:e954893.1-e954893.12(2014).
//
RX   PubMed=16397213; DOI=10.1158/0008-5472.CAN-05-2853;
RA   Elstrodt, Fons
RA   Hollestelle, Antoinette
RA   Nagel, Jord H.A.
RA   Gorin, Michael
RA   Wasielewski, Marijke
RA   van den Ouweland, Ans M.W.
RA   Merajver, Sofia Diana
RA   Ethier, Stephen P.
RA   Schutte, Mieke
RT   "BRCA1 mutation analysis of 41 human breast cancer cell lines reveals
RT   three new deleterious mutants.";
RL   Cancer Res. 66:41-45(2006).
//
RX   PubMed=32715085; DOI=10.1038/s41523-020-0173-z; PMCID=PMC7374090;
RA   Ethier, Stephen P.
RA   Guest, Stephen T.
RA   Garrett-Mayer, Elizabeth
RA   Armeson, Kent
RA   Wilson, Robert C.
RA   Duchinski, Kathryn
RA   Couch, Daniel
RA   Gray, Joe W.
RA   Kappler, Christiana S.
RT   "Development and implementation of the SUM breast cancer cell line
RT   functional genomics knowledge base.";
RL   NPJ Breast Cancer 6:30.1-30.14(2020).
//
RX   PubMed=19593635; DOI=10.1007/s10549-009-0460-8;
RA   Hollestelle, Antoinette
RA   Nagel, Jord H.A.
RA   Smid, Marcel
RA   Lam, Suzanne
RA   Elstrodt, Fons
RA   Wasielewski, Marijke
RA   Ng, Ser Sue
RA   French, Pim J.
RA   Peeters, Justine K.
RA   Rozendaal, Marieke J.
RA   Riaz, Muhammad
RA   Koopman, Daphne G.
RA   ten Hagen, Timo L.M.
RA   de Leeuw, Bertie H.C.G.M.
RA   Zwarthoff, Ellen C.
RA   Teunisse, Amina F.A.S.
RA   van der Spek, Peter J.
RA   Klijn, Jan G.M.
RA   Dinjens, Winand N.M.
RA   Ethier, Stephen P.
RA   Clevers, Hans Cornelius
RA   Jochemsen, Aart G.
RA   den Bakker, Michael A.
RA   Foekens, John A.
RA   Martens, John W.M.
RA   Schutte, Mieke
RT   "Distinct gene mutation profiles among luminal-type and basal-type
RT   breast cancer cell lines.";
RL   Breast Cancer Res. Treat. 121:53-64(2010).
//