ID   WSU-HN8
AC   CVCL_5517
SY   HN8; Wayne State University-Head and Neck 8
DR   cancercelllines; CVCL_5517
DR   Cosmic; 922080
DR   Cosmic; 2296296
DR   Wikidata; Q54994491
RX   PubMed=7705939;
RX   PubMed=8001221;
RX   PubMed=9389571;
RX   PubMed=25275298;
CC   Part of: OPC-22 oral and pharyngeal cancer cell line panel.
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg196Ter (c.586C>T); ClinVar=VCV000043589; Zygosity=Unspecified (PubMed=25275298).
CC   Omics: Deep exome analysis.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
ST   Source(s): PubMed=25275298
ST   Amelogenin: X,Y
ST   CSF1PO: 12,13
ST   D13S317: 13
ST   D16S539: 9,12
ST   D18S51: 13,19
ST   D21S11: 30
ST   D3S1358: 17
ST   D5S818: 11,12
ST   D7S820: 8
ST   D8S1179: 11,12
ST   FGA: 22
ST   Penta D: 15
ST   Penta E: 5,13
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C4833; Oral cavity squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_5522 ! WSU-HN22
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 04-04-12; Last updated: 05-10-23; Version: 16
//
RX   PubMed=7705939; DOI=10.1002/ijc.2910610117;
RA   Cardinali M., Pietraszkiewicz H., Ensley J.F., Robbins K.C.;
RT   "Tyrosine phosphorylation as a marker for aberrantly regulated
RT   growth-promoting pathways in cell lines derived from head and neck
RT   malignancies.";
RL   Int. J. Cancer 61:98-103(1995).
//
RX   PubMed=8001221; DOI=10.1093/carcin/15.12.2683;
RA   Yeudall W.A., Crawford R.Y., Ensley J.F., Robbins K.C.;
RT   "MTS1/CDK4I is altered in cell lines derived from primary and
RT   metastatic oral squamous cell carcinoma.";
RL   Carcinogenesis 15:2683-2686(1994).
//
RX   PubMed=9389571; DOI=10.1002/(SICI)1097-0215(19971114)73:4<551::AID-IJC16>3.0.CO;2-C;
RA   Patel V., Jakus J., Harris C.M., Ensley J.F., Robbins K.C.,
RA   Yeudall W.A.;
RT   "Altered expression and activity of G1/S cyclins and cyclin-dependent
RT   kinases characterize squamous cell carcinomas of the head and neck.";
RL   Int. J. Cancer 73:551-555(1997).
//
RX   PubMed=25275298; DOI=10.18632/oncotarget.2417;
RA   Martin D., Abba M.C., Molinolo A.A., Vitale-Cross L., Wang Z.-Y.,
RA   Zaida M., Delic N.C., Samuels Y., Lyons J.G., Gutkind J.S.;
RT   "The head and neck cancer cell oncogenome: a platform for the
RT   development of precision molecular therapies.";
RL   Oncotarget 5:8906-8923(2014).
//